1fml
From Proteopedia
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[[Image:1fml.gif|left|200px]] | [[Image:1fml.gif|left|200px]] | ||
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'''CRYSTAL STRUCTURE OF RETINOL DEHYDRATASE IN A COMPLEX WITH RETINOL AND PAP''' | '''CRYSTAL STRUCTURE OF RETINOL DEHYDRATASE IN A COMPLEX WITH RETINOL AND PAP''' | ||
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[[Category: Newcomer, M E.]] | [[Category: Newcomer, M E.]] | ||
[[Category: Pakhomova, S.]] | [[Category: Pakhomova, S.]] | ||
| - | [[Category: | + | [[Category: Adenosine 3',5'-diphosphate]] |
| - | [[Category: | + | [[Category: Dehydratase]] |
| - | [[Category: | + | [[Category: Retinol]] |
| - | [[Category: | + | [[Category: Sulfotransferase]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 16:30:32 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 13:30, 2 May 2008
CRYSTAL STRUCTURE OF RETINOL DEHYDRATASE IN A COMPLEX WITH RETINOL AND PAP
Overview
We report here the crystal structure of retinol dehydratase, an enzyme that catalyzes the synthesis of anhydroretinol. The enzyme is a member of the sulfotransferase superfamily and its crystal structure reveals the insertion of a helical lid into a canonical sulfotransferase fold. Site-directed mutations demonstrate that this inserted lid is necessary for anhydroretinol production but not for sulfonation; thus, insertion of a helical lid can convert a sulfotransferase into a dehydratase.
About this Structure
1FML is a Single protein structure of sequence from Spodoptera frugiperda. Full crystallographic information is available from OCA.
Reference
A helical lid converts a sulfotransferase to a dehydratase., Pakhomova S, Kobayashi M, Buck J, Newcomer ME, Nat Struct Biol. 2001 May;8(5):447-51. PMID:11323722 Page seeded by OCA on Fri May 2 16:30:32 2008
