Mitogen-activated protein kinase kinase kinase

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**[[2rf0]] - hMAP3K10 SH3 domain - NMR
**[[2rf0]] - hMAP3K10 SH3 domain - NMR
 +
 +
*MAP3K11
 +
 +
**[[6cq7]] - hMAP3K11 SH3 domain/huntington fusion peptide<br />
 +
 +
*MAP3K12 kinase domain 115-402
 +
 +
**[[5cen]] - hMAP3K12 <br />
 +
**[[5ceo]] - hMAP3K12 + inhibitor<br />
*MAP3K14 kinase domain 343-686
*MAP3K14 kinase domain 343-686
**[[4dn5]] - hMAP3K14 (mutant) + ATP-γ-S<br />
**[[4dn5]] - hMAP3K14 (mutant) + ATP-γ-S<br />
-
**[[4idt]], [[4idv]], [[6wpp]] - hMAP3K14 + inhibitor<br />
+
**[[4idt]], [[4idv]], [[6wpp]], [[6z1q]], [[6z1t]] - hMAP3K14 + inhibitor<br />
**[[6g4y]], [[6g4z]], [[6myn]] - mMAP3K14 + inhibitor<br />
**[[6g4y]], [[6g4z]], [[6myn]] - mMAP3K14 + inhibitor<br />

Revision as of 08:55, 4 November 2021

Mitogen-activated protein kinase kinase kinase 3 (green) complex with MAP2K5 PHOX domain (grey) (PDB code 2o2v).

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3D Structures of Mitogen-activated protein kinase kinase kinase

Updated on 04-November-2021

References

  1. ↑ Ellinger-Ziegelbauer H, Brown K, Kelly K, Siebenlist U. Direct activation of the stress-activated protein kinase (SAPK) and extracellular signal-regulated protein kinase (ERK) pathways by an inducible mitogen-activated protein Kinase/ERK kinase kinase 3 (MEKK) derivative. J Biol Chem. 1997 Jan 31;272(5):2668-74. PMID:9006902
  2. ↑ Santen RJ, Song RX, McPherson R, Kumar R, Adam L, Jeng MH, Yue W. The role of mitogen-activated protein (MAP) kinase in breast cancer. J Steroid Biochem Mol Biol. 2002 Feb;80(2):239-56. PMID:11897507

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Michal Harel, Alexander Berchansky, Joel L. Sussman

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