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1fnf

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{{Structure
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1fnf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fnf OCA], [http://www.ebi.ac.uk/pdbsum/1fnf PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1fnf RCSB]</span>
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'''FRAGMENT OF HUMAN FIBRONECTIN ENCOMPASSING TYPE-III REPEATS 7 THROUGH 10'''
'''FRAGMENT OF HUMAN FIBRONECTIN ENCOMPASSING TYPE-III REPEATS 7 THROUGH 10'''
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[[Category: Erickson, H P.]]
[[Category: Erickson, H P.]]
[[Category: Leahy, D J.]]
[[Category: Leahy, D J.]]
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[[Category: extracellular matrix]]
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[[Category: Extracellular matrix]]
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[[Category: rgd]]
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[[Category: Rgd]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 16:32:07 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 20:26:25 2008''
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Revision as of 13:32, 2 May 2008

Image:1fnf.gif

Template:STRUCTURE 1fnf

FRAGMENT OF HUMAN FIBRONECTIN ENCOMPASSING TYPE-III REPEATS 7 THROUGH 10


Overview

We have determined the 2.0 A crystal structure of a fragment of human fibronectin encompassing the seventh through the RGD-containing tenth type III repeats (FN7-10). The structure reveals an extended rod-like molecule with a long axis of approximately 140 A and highly variable relationships between adjacent domains. An unusually small rotation between domains 9 and 10 creates a distinctive binding site, in which the RGD loop from domain 10 and the "synergy" region from domain 9 are on the same face of FN7-10 and thus easily accessible to a single integrin molecule. The cell-binding RGD loop is well-ordered in this structure and extends approximately 10 A away from the FN7-10 core.

About this Structure

1FNF is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

2.0 A crystal structure of a four-domain segment of human fibronectin encompassing the RGD loop and synergy region., Leahy DJ, Aukhil I, Erickson HP, Cell. 1996 Jan 12;84(1):155-64. PMID:8548820 Page seeded by OCA on Fri May 2 16:32:07 2008

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