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1fnl

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[[Image:1fnl.gif|left|200px]]
[[Image:1fnl.gif|left|200px]]
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{{Structure
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{{STRUCTURE_1fnl| PDB=1fnl | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1fnl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fnl OCA], [http://www.ebi.ac.uk/pdbsum/1fnl PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1fnl RCSB]</span>
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'''CRYSTAL STRUCTURE OF THE EXTRACELLULAR DOMAIN OF A HUMAN FCGRIII'''
'''CRYSTAL STRUCTURE OF THE EXTRACELLULAR DOMAIN OF A HUMAN FCGRIII'''
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[[Category: Sun, P D.]]
[[Category: Sun, P D.]]
[[Category: Zhang, Y.]]
[[Category: Zhang, Y.]]
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[[Category: beta sandwich]]
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[[Category: Beta sandwich]]
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[[Category: immunoglobulin-like]]
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[[Category: Immunoglobulin-like]]
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[[Category: receptor]]
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[[Category: Receptor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 16:32:26 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 20:26:32 2008''
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Revision as of 13:32, 2 May 2008

Image:1fnl.gif

Template:STRUCTURE 1fnl

CRYSTAL STRUCTURE OF THE EXTRACELLULAR DOMAIN OF A HUMAN FCGRIII


Overview

Fc receptors play a major role in immune defenses against pathogens and in inflammatory processes. The crystal structure of a human immunoglobulin receptor, FcgammaRIIIb, has been determined to 1.8 A resolution. The overall fold consists of two immunoglobulin-like domains with an acute interdomain hinge angle of approximately 50 degrees. Trp-113, wedged between the N-terminal D1 and the C-terminal D2 domains, appears to further restrict the hinge angle. The putative Fc binding region of the receptor carries a net positive charge complementary to the negative-charged receptor binding regions on Fc. A 1:1 binding stoichiometry between the receptor and Fc was measured by both the equilibrium and nonequilibrium size-exclusion chromatography. Two separate parallel dimers are observed in the crystal lattice, offering intriguing models for receptor aggregation.

About this Structure

1FNL is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of the extracellular domain of a human Fc gamma RIII., Zhang Y, Boesen CC, Radaev S, Brooks AG, Fridman WH, Sautes-Fridman C, Sun PD, Immunity. 2000 Sep;13(3):387-95. PMID:11021536 Page seeded by OCA on Fri May 2 16:32:26 2008

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