1fnn
From Proteopedia
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'''CRYSTAL STRUCTURE OF CDC6P FROM PYROBACULUM AEROPHILUM''' | '''CRYSTAL STRUCTURE OF CDC6P FROM PYROBACULUM AEROPHILUM''' | ||
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[[Category: Martin, G S.]] | [[Category: Martin, G S.]] | ||
[[Category: Smith, C L.]] | [[Category: Smith, C L.]] | ||
| - | [[Category: | + | [[Category: Aaa protein]] |
| - | [[Category: | + | [[Category: Cdc18]] |
| - | [[Category: | + | [[Category: Cdc6]] |
| - | [[Category: | + | [[Category: Cell cycle control factor]] |
| - | [[Category: | + | [[Category: Dna replication initation factor]] |
| - | [[Category: | + | [[Category: Orc1]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 16:32:27 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 13:32, 2 May 2008
CRYSTAL STRUCTURE OF CDC6P FROM PYROBACULUM AEROPHILUM
Overview
Cdc6/Cdc18 is a conserved and essential component of prereplication complexes. The 2.0 A crystal structure of an archaeal Cdc6 ortholog, in conjunction with a mutational analysis of the homologous Cdc18 protein from Schizosaccharomyces pombe, reveals novel aspects of Cdc6/Cdc18 function. Two domains of Cdc6 form an AAA+-type nucleotide binding fold that is observed bound to Mg.ADP. A third domain adopts a winged-helix fold similar to known DNA binding modules. Sequence comparisons show that the winged-helix domain is conserved in Orc1, and mutagenesis data demonstrate that this region of Cdc6/Cdc18 is required for function in vivo. Additional mutational analyses suggest that nucleotide binding and/or hydrolysis by Cdc6/Cdc18 is required not only for progression through S phase, but also for maintenance of checkpoint control during S phase.
About this Structure
1FNN is a Single protein structure of sequence from Pyrobaculum aerophilum. Full crystallographic information is available from OCA.
Reference
Structure and function of Cdc6/Cdc18: implications for origin recognition and checkpoint control., Liu J, Smith CL, DeRyckere D, DeAngelis K, Martin GS, Berger JM, Mol Cell. 2000 Sep;6(3):637-48. PMID:11030343 Page seeded by OCA on Fri May 2 16:32:27 2008
