1v5m
From Proteopedia
(Difference between revisions)
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<StructureSection load='1v5m' size='340' side='right'caption='[[1v5m]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | <StructureSection load='1v5m' size='340' side='right'caption='[[1v5m]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[1v5m]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[1v5m]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1V5M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1V5M FirstGlance]. <br> |
| - | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">RIKEN cDNA 5730427K19 ([ | + | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">RIKEN cDNA 5730427K19 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1v5m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1v5m OCA], [https://pdbe.org/1v5m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1v5m RCSB], [https://www.ebi.ac.uk/pdbsum/1v5m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1v5m ProSAT], [https://www.topsan.org/Proteins/RSGI/1v5m TOPSAN]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/SH2B2_MOUSE SH2B2_MOUSE]] Adapter protein for several members of the tyrosine kinase receptor family. Involved in multiple signaling pathways. May be involved in coupling from immunoreceptor to Ras signaling. Acts as a negative regulator of cytokine signaling in collaboration with CBL. Binds to EPOR and suppresses EPO-induced STAT5 activation, possibly through a masking effect on STAT5 docking sites in EPOR. Suppresses PDGF-induced mitogenesis. May induce cytoskeletal reorganization via interaction with VAV3 (By similarity). |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Revision as of 06:33, 10 November 2021
Solution Structure of the Pleckstrin Homology Domain of Mouse APS
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