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2d9q

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<StructureSection load='2d9q' size='340' side='right'caption='[[2d9q]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
<StructureSection load='2d9q' size='340' side='right'caption='[[2d9q]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2d9q]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2D9Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2D9Q FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2d9q]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2D9Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2D9Q FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2d9q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2d9q OCA], [http://pdbe.org/2d9q PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2d9q RCSB], [http://www.ebi.ac.uk/pdbsum/2d9q PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2d9q ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2d9q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2d9q OCA], [https://pdbe.org/2d9q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2d9q RCSB], [https://www.ebi.ac.uk/pdbsum/2d9q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2d9q ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
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[[http://www.uniprot.org/uniprot/CSF3R_HUMAN CSF3R_HUMAN]] Defects in CSF3R are the cause of hereditary neutrophilia (NEUTROPHILIA) [MIM:[http://omim.org/entry/162830 162830]]. A form of lifelong, persistent neutrophilia, a condition characterized by an increase in the number of neutrophils in the blood.<ref>PMID:19620628</ref>
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[[https://www.uniprot.org/uniprot/CSF3R_HUMAN CSF3R_HUMAN]] Defects in CSF3R are the cause of hereditary neutrophilia (NEUTROPHILIA) [MIM:[https://omim.org/entry/162830 162830]]. A form of lifelong, persistent neutrophilia, a condition characterized by an increase in the number of neutrophils in the blood.<ref>PMID:19620628</ref>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/CSF3_HUMAN CSF3_HUMAN]] Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. This CSF induces granulocytes. [[http://www.uniprot.org/uniprot/CSF3R_HUMAN CSF3R_HUMAN]] Receptor for granulocyte colony-stimulating factor (CSF3), essential for granulocytic maturation. Plays a crucial role in the proliferation, differientation and survival of cells along the neutrophilic lineage. In addition it may function in some adhesion or recognition events at the cell surface.<ref>PMID:7514305</ref>
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[[https://www.uniprot.org/uniprot/CSF3_HUMAN CSF3_HUMAN]] Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. This CSF induces granulocytes. [[https://www.uniprot.org/uniprot/CSF3R_HUMAN CSF3R_HUMAN]] Receptor for granulocyte colony-stimulating factor (CSF3), essential for granulocytic maturation. Plays a crucial role in the proliferation, differientation and survival of cells along the neutrophilic lineage. In addition it may function in some adhesion or recognition events at the cell surface.<ref>PMID:7514305</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]

Revision as of 06:49, 10 November 2021

Crystal Structure of the Human GCSF-Receptor Signaling Complex

PDB ID 2d9q

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