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2k9e
From Proteopedia
(Difference between revisions)
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<StructureSection load='2k9e' size='340' side='right'caption='[[2k9e]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | <StructureSection load='2k9e' size='340' side='right'caption='[[2k9e]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2k9e]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K9E OCA]. For a <b>guided tour on the structure components</b> use [ | + | <table><tr><td colspan='2'>[[2k9e]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K9E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2K9E FirstGlance]. <br> |
</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene>, <scene name='pdbligand=NLE:NORLEUCINE'>NLE</scene>, <scene name='pdbligand=PFX:(2S)-1-({2-[2-(CARBOXYMETHOXY)ETHOXY]ETHYL}AMINO)-1-OXO-3-(4-PHOSPHONOPHENYL)PROPAN-2-AMINIUM'>PFX</scene></td></tr> | </td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene>, <scene name='pdbligand=NLE:NORLEUCINE'>NLE</scene>, <scene name='pdbligand=PFX:(2S)-1-({2-[2-(CARBOXYMETHOXY)ETHOXY]ETHYL}AMINO)-1-OXO-3-(4-PHOSPHONOPHENYL)PROPAN-2-AMINIUM'>PFX</scene></td></tr> | ||
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2k9e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2k9e OCA], [https://pdbe.org/2k9e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2k9e RCSB], [https://www.ebi.ac.uk/pdbsum/2k9e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2k9e ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/TXSHK_STOHE TXSHK_STOHE]] Inhibits voltage-dependent potassium channels. Inhibits Kv1.3/KCNA3 potently and also blocks Kv1.1/KCNA1, Kv1.4/KCNA4, and Kv1.6/KCNA6 at subnanomolar concentrations.<ref>PMID:7660365</ref> |
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
Revision as of 07:02, 10 November 2021
NMR Solution Structure for ShK-192: A Potent KV1.3-Specific Immunosuppressive Polypeptide
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