1fo0
From Proteopedia
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[[Image:1fo0.gif|left|200px]] | [[Image:1fo0.gif|left|200px]] | ||
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'''MURINE ALLOREACTIVE SCFV TCR-PEPTIDE-MHC CLASS I MOLECULE COMPLEX''' | '''MURINE ALLOREACTIVE SCFV TCR-PEPTIDE-MHC CLASS I MOLECULE COMPLEX''' | ||
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[[Category: Reiser, J B.]] | [[Category: Reiser, J B.]] | ||
[[Category: Schmitt-Verhulst, A-M.]] | [[Category: Schmitt-Verhulst, A-M.]] | ||
| - | [[Category: | + | [[Category: Class i mhc]] |
| - | [[Category: | + | [[Category: H-2kb]] |
| - | [[Category: | + | [[Category: T cell receptor]] |
| - | [[Category: | + | [[Category: Tcr-pmhc complex]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 16:33:24 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 13:33, 2 May 2008
MURINE ALLOREACTIVE SCFV TCR-PEPTIDE-MHC CLASS I MOLECULE COMPLEX
Overview
Many T cell receptors (TCRs) that are selected to respond to foreign peptide antigens bound to self major histocompatibility complex (MHC) molecules are also reactive with allelic variants of self-MHC molecules. This property, termed alloreactivity, causes graft rejection and graft-versus-host disease. The structural features of alloreactivity have yet to be defined. We now present a basis for this cross-reactivity, elucidated by the crystal structure of a complex involving the BM3.3 TCR and a naturally processed octapeptide bound to the H-2Kb allogeneic MHC class I molecule. A distinguishing feature of this complex is that the eleven-residue-long complementarity-determining region 3 (CDR3) found in the BM3.3 TCR alpha chain folds away from the peptide binding groove and makes no contact with the bound peptide, the latter being exclusively contacted by the BM3.3 CDR3 beta. Our results formally establish that peptide-specific, alloreactive TCRs interact with allo-MHC in a register similar to the one they use to contact self-MHC molecules.
About this Structure
1FO0 is a Protein complex structure of sequences from Mus musculus. Full crystallographic information is available from OCA.
Reference
Crystal structure of a T cell receptor bound to an allogeneic MHC molecule., Reiser JB, Darnault C, Guimezanes A, Gregoire C, Mosser T, Schmitt-Verhulst AM, Fontecilla-Camps JC, Malissen B, Housset D, Mazza G, Nat Immunol. 2000 Oct;1(4):291-7. PMID:11017099 Page seeded by OCA on Fri May 2 16:33:24 2008
