2zjz
From Proteopedia
(Difference between revisions)
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==Structure of the K349P mutant of Gi alpha 1 subunit bound to GDP== | ==Structure of the K349P mutant of Gi alpha 1 subunit bound to GDP== | ||
| - | <StructureSection load='2zjz' size='340' side='right' caption='[[2zjz]], [[Resolution|resolution]] 2.60Å' scene=''> | + | <StructureSection load='2zjz' size='340' side='right'caption='[[2zjz]], [[Resolution|resolution]] 2.60Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2zjz]] is a 2 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[2zjz]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZJZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ZJZ FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene></td></tr> |
| - | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1bof|1bof]], [[1gdd|1gdd]], [[1gp2|1gp2]], [[2zjy|2zjy]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1bof|1bof]], [[1gdd|1gdd]], [[1gp2|1gp2]], [[2zjy|2zjy]]</div></td></tr> |
| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Gnai1, Gnai-1 ([ | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Gnai1, Gnai-1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr> |
| - | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Heterotrimeric_G-protein_GTPase Heterotrimeric G-protein GTPase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.5.1 3.6.5.1] </span></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2zjz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zjz OCA], [https://pdbe.org/2zjz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2zjz RCSB], [https://www.ebi.ac.uk/pdbsum/2zjz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2zjz ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/GNAI1_RAT GNAI1_RAT]] Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. The inactive GDP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division.<ref>PMID:16870394</ref> |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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[[Category: Buffalo rat]] | [[Category: Buffalo rat]] | ||
[[Category: Heterotrimeric G-protein GTPase]] | [[Category: Heterotrimeric G-protein GTPase]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Kohno, T]] | [[Category: Kohno, T]] | ||
[[Category: Morikawa, T]] | [[Category: Morikawa, T]] | ||
Revision as of 07:17, 10 November 2021
Structure of the K349P mutant of Gi alpha 1 subunit bound to GDP
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