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| | <StructureSection load='1zgs' size='340' side='right'caption='[[1zgs]], [[Resolution|resolution]] 2.50Å' scene=''> | | <StructureSection load='1zgs' size='340' side='right'caption='[[1zgs]], [[Resolution|resolution]] 2.50Å' scene=''> |
| | == Structural highlights == | | == Structural highlights == |
| - | <table><tr><td colspan='2'>[[1zgs]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Parkia_platycephala Parkia platycephala]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZGS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ZGS FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[1zgs]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Parkia_platycephala Parkia platycephala]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZGS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ZGS FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=XMM:(2R,3S,4S,5S,6R)-2-(5-BROMO-4-CHLORO-1H-INDOL-3-YLOXY)-TETRAHYDRO-6-(HYDROXYMETHYL)-2H-PYRAN-3,4,5-TRIOL'>XMM</scene></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=XMM:(2R,3S,4S,5S,6R)-2-(5-BROMO-4-CHLORO-1H-INDOL-3-YLOXY)-TETRAHYDRO-6-(HYDROXYMETHYL)-2H-PYRAN-3,4,5-TRIOL'>XMM</scene></td></tr> |
| - | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1zgr|1zgr]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1zgr|1zgr]]</div></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zgs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zgs OCA], [http://pdbe.org/1zgs PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1zgs RCSB], [http://www.ebi.ac.uk/pdbsum/1zgs PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1zgs ProSAT]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1zgs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zgs OCA], [https://pdbe.org/1zgs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1zgs RCSB], [https://www.ebi.ac.uk/pdbsum/1zgs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1zgs ProSAT]</span></td></tr> |
| | </table> | | </table> |
| | == Function == | | == Function == |
| - | [[http://www.uniprot.org/uniprot/LEC_PARPC LEC_PARPC]] Mannose/glucose specific lectin. Shows agglutinating activity against rabbit erythrocytes.<ref>PMID:11502201</ref> | + | [[https://www.uniprot.org/uniprot/LEC_PARPC LEC_PARPC]] Mannose/glucose specific lectin. Shows agglutinating activity against rabbit erythrocytes.<ref>PMID:11502201</ref> |
| | == Evolutionary Conservation == | | == Evolutionary Conservation == |
| | [[Image:Consurf_key_small.gif|200px|right]] | | [[Image:Consurf_key_small.gif|200px|right]] |
| Structural highlights
Function
[LEC_PARPC] Mannose/glucose specific lectin. Shows agglutinating activity against rabbit erythrocytes.[1]
Evolutionary Conservation
Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.
Publication Abstract from PubMed
The crystal structures of the apo and mannose-bound Parkia platycephala seed lectin represent the first structure of a Mimosoideae lectin and a novel circular arrangement of beta-prism domains, and highlight the adaptability of the beta-prism fold as a building block in the evolution of plant lectins. The P.platycephala lectin is a dimer both in solution and in the crystals. Mannose binding to each of the three homologous carbohydrate-recognition domains of the lectin occurs through different modes, and restrains the flexibility of surface-exposed loops and residues involved in carbohydrate recognition. The planar array of carbohydrate-binding sites on the rim of the toroid-shaped structure of the P.platycephala lectin dimer immediately suggests a mechanism to promote multivalent interactions leading to cross-linking of carbohydrate ligands as part of the host strategy against phytopredators and pathogens. The cyclic structure of the P.platycephala lectin points to the convergent evolution of a structural principle for the construction of lectins involved in host defense or in attacking other organisms.
The first crystal structure of a Mimosoideae lectin reveals a novel quaternary arrangement of a widespread domain.,Gallego del Sol F, Nagano C, Cavada BS, Calvete JJ J Mol Biol. 2005 Oct 28;353(3):574-83. Epub 2005 Sep 9. PMID:16185708[2]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Mann K, Farias CM, Del Sol FG, Santos CF, Grangeiro TB, Nagano CS, Cavada BS, Calvete JJ. The amino-acid sequence of the glucose/mannose-specific lectin isolated from Parkia platycephala seeds reveals three tandemly arranged jacalin-related domains. Eur J Biochem. 2001 Aug;268(16):4414-22. PMID:11502201
- ↑ Gallego del Sol F, Nagano C, Cavada BS, Calvete JJ. The first crystal structure of a Mimosoideae lectin reveals a novel quaternary arrangement of a widespread domain. J Mol Biol. 2005 Oct 28;353(3):574-83. Epub 2005 Sep 9. PMID:16185708 doi:10.1016/j.jmb.2005.08.055
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