1fos

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[[Image:1fos.gif|left|200px]]
[[Image:1fos.gif|left|200px]]
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{{Structure
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|PDB= 1fos |SIZE=350|CAPTION= <scene name='initialview01'>1fos</scene>, resolution 3.050&Aring;
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The line below this paragraph, containing "STRUCTURE_1fos", creates the "Structure Box" on the page.
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|SITE=
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|LIGAND= <scene name='pdbligand=DA:2&#39;-DEOXYADENOSINE-5&#39;-MONOPHOSPHATE'>DA</scene>, <scene name='pdbligand=DC:2&#39;-DEOXYCYTIDINE-5&#39;-MONOPHOSPHATE'>DC</scene>, <scene name='pdbligand=DG:2&#39;-DEOXYGUANOSINE-5&#39;-MONOPHOSPHATE'>DG</scene>, <scene name='pdbligand=DT:THYMIDINE-5&#39;-MONOPHOSPHATE'>DT</scene>
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{{STRUCTURE_1fos| PDB=1fos | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1fos FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fos OCA], [http://www.ebi.ac.uk/pdbsum/1fos PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1fos RCSB]</span>
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'''TWO HUMAN C-FOS:C-JUN:DNA COMPLEXES'''
'''TWO HUMAN C-FOS:C-JUN:DNA COMPLEXES'''
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[[Category: Glover, J N.M.]]
[[Category: Glover, J N.M.]]
[[Category: Harrison, S C.]]
[[Category: Harrison, S C.]]
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[[Category: coiled-coil]]
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[[Category: Coiled-coil]]
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[[Category: dna-binding protein]]
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[[Category: Dna-binding protein]]
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[[Category: heterodimer]]
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[[Category: Heterodimer]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 16:35:14 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 20:27:12 2008''
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Revision as of 13:35, 2 May 2008

Image:1fos.gif

Template:STRUCTURE 1fos

TWO HUMAN C-FOS:C-JUN:DNA COMPLEXES


Overview

The Fos and Jun families of eukaryotic transcription factors heterodimerize to form complexes capable of binding 5'-TGAGTCA-3' DNA elements. We have determined the X-ray crystal structure of a heterodimer of the bZIP regions of c-Fos and c-Jun bound to DNA. Both subunits form continuous alpha-helices. The carboxy-terminal regions form an asymmetric coiled-coil, and the amino-terminal regions make base-specific contacts with DNA in the major groove. Comparison of the two crystallographically distinct protein-DNA complexes show that the coiled-coil is flexibly joined to the basic regions and that the Fos-Jun heterodimer does not recognize the asymmetric 5'-TGAGTCA-3' recognition element in a unique orientation. There is an extensive network of electrostatic interactions between subunits within the coiled-coil, consistent with proposals that these interactions determine preferential formation of the heterodimer over either of the homodimers.

About this Structure

1FOS is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of the heterodimeric bZIP transcription factor c-Fos-c-Jun bound to DNA., Glover JN, Harrison SC, Nature. 1995 Jan 19;373(6511):257-61. PMID:7816143 Page seeded by OCA on Fri May 2 16:35:14 2008

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