2xd7
From Proteopedia
(Difference between revisions)
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<StructureSection load='2xd7' size='340' side='right'caption='[[2xd7]], [[Resolution|resolution]] 2.09Å' scene=''> | <StructureSection load='2xd7' size='340' side='right'caption='[[2xd7]], [[Resolution|resolution]] 2.09Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2xd7]] is a 4 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[2xd7]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XD7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XD7 FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xd7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xd7 OCA], [https://pdbe.org/2xd7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xd7 RCSB], [https://www.ebi.ac.uk/pdbsum/2xd7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xd7 ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/H2AW_HUMAN H2AW_HUMAN]] Variant histone H2A which replaces conventional H2A in a subset of nucleosomes where it represses transcription. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in stable X chromosome inactivation.<ref>PMID:15621527</ref> |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Revision as of 08:38, 10 November 2021
Crystal structure of the macro domain of human core histone H2A
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Categories: Human | Large Structures | Arrowsmith, C H | Bountra, C | Carpenter, E P | Delft, F von | Edwards, A | Gileadi, O | Krojer, T | Muniz, J R.C | Phillips, C | Ugochukwu, E | Vollmar, M | Weigelt, J | Chromatin regulator | Chromosomal protein | Dna binding protein | Dna-binding protein | Nucleosome core | Nucleus | Phosphoprotein
