1fpv
From Proteopedia
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'''STRUCTURE DETERMINATION OF FELINE PANLEUKOPENIA VIRUS EMPTY PARTICLES''' | '''STRUCTURE DETERMINATION OF FELINE PANLEUKOPENIA VIRUS EMPTY PARTICLES''' | ||
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[[Category: Agbandje, M.]] | [[Category: Agbandje, M.]] | ||
[[Category: Rossmann, M G.]] | [[Category: Rossmann, M G.]] | ||
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| - | [[Category: | + | [[Category: Panleukemia virus coat protein]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 16:37:29 2008'' | |
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Revision as of 13:37, 2 May 2008
STRUCTURE DETERMINATION OF FELINE PANLEUKOPENIA VIRUS EMPTY PARTICLES
Overview
Various crystal forms of the single-stranded DNA, feline panleukopenia virus (FPV), a parvovirus, have been grown of both full virions and empty particles. The structure of empty particles crystallized in an orthorhombic space group P2(1)2(1)2(1), with unit cell dimensions a = 380.1 A, b = 379.3 A, and c = 350.9 A, has been determined to 3.3 A resolution. The data were collected using oscillation photography with synchrotron radiation. The orientations of the empty capsids in the unit cell were determined using a self-rotation function and their positions were obtained with an R-factor search using canine parvovirus (CPV) as a model. Phases were then calculated, based on the CPV model, to 6.0 A resolution and gradually extended to 3.3 A resolution by molecular replacement electron density averaging. The resultant electron density was readily interpreted in terms of the known amino acid sequence. The structure is contrasted to that of CPV in terms of host range, neutralization by antibodies, hemagglutination properties, and binding of genomic DNA.
About this Structure
1FPV is a Single protein structure of sequence from Feline panleukopenia virus. Full crystallographic information is available from OCA.
Reference
Structure determination of feline panleukopenia virus empty particles., Agbandje M, McKenna R, Rossmann MG, Strassheim ML, Parrish CR, Proteins. 1993 Jun;16(2):155-71. PMID:8392729 Page seeded by OCA on Fri May 2 16:37:29 2008
