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1fq9

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[[Image:1fq9.jpg|left|200px]]
[[Image:1fq9.jpg|left|200px]]
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{{Structure
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|PDB= 1fq9 |SIZE=350|CAPTION= <scene name='initialview01'>1fq9</scene>, resolution 3.0&Aring;
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The line below this paragraph, containing "STRUCTURE_1fq9", creates the "Structure Box" on the page.
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|LIGAND= <scene name='pdbligand=IDU:1,4-DIDEOXY-O2-SULFO-GLUCURONIC+ACID'>IDU</scene>, <scene name='pdbligand=SGN:N,O6-DISULFO-GLUCOSAMINE'>SGN</scene>, <scene name='pdbligand=UAP:1,4-DIDEOXY-5-DEHYDRO-O2-SULFO-GLUCURONIC+ACID'>UAP</scene>
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{{STRUCTURE_1fq9| PDB=1fq9 | SCENE= }}
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|RELATEDENTRY=[[1cvs|1CVS]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1fq9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fq9 OCA], [http://www.ebi.ac.uk/pdbsum/1fq9 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1fq9 RCSB]</span>
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'''CRYSTAL STRUCTURE OF A TERNARY FGF2-FGFR1-HEPARIN COMPLEX'''
'''CRYSTAL STRUCTURE OF A TERNARY FGF2-FGFR1-HEPARIN COMPLEX'''
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[[Category: Yayon, A.]]
[[Category: Yayon, A.]]
[[Category: Yeh, B K.]]
[[Category: Yeh, B K.]]
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[[Category: b-trefoil fold]]
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[[Category: B-trefoil fold]]
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[[Category: i-set subgroup within the immunoglobulin superfamily]]
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[[Category: I-set subgroup within the immunoglobulin superfamily]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 16:38:20 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 20:28:14 2008''
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Revision as of 13:38, 2 May 2008

Image:1fq9.jpg

Template:STRUCTURE 1fq9

CRYSTAL STRUCTURE OF A TERNARY FGF2-FGFR1-HEPARIN COMPLEX


Overview

The crystal structure of a dimeric 2:2:2 FGF:FGFR:heparin ternary complex at 3 A resolution has been determined. Within each 1:1 FGF:FGFR complex, heparin makes numerous contacts with both FGF and FGFR, thereby augmenting FGF-FGFR binding. Heparin also interacts with FGFR in the adjoining 1:1 FGF:FGFR complex to promote FGFR dimerization. The 6-O-sulfate group of heparin plays a pivotal role in mediating both interactions. The unexpected stoichiometry of heparin binding in the structure led us to propose a revised model for FGFR dimerization. Biochemical data in support of this model are also presented. This model provides a structural basis for FGFR activation by small molecule heparin analogs and may facilitate the design of heparin mimetics capable of modulating FGF signaling.

About this Structure

1FQ9 is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of a ternary FGF-FGFR-heparin complex reveals a dual role for heparin in FGFR binding and dimerization., Schlessinger J, Plotnikov AN, Ibrahimi OA, Eliseenkova AV, Yeh BK, Yayon A, Linhardt RJ, Mohammadi M, Mol Cell. 2000 Sep;6(3):743-50. PMID:11030354 Page seeded by OCA on Fri May 2 16:38:20 2008

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