7lna
From Proteopedia
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==Infectious mammalian prion fibril (263K scrapie)== | ==Infectious mammalian prion fibril (263K scrapie)== | ||
| - | <StructureSection load='7lna' size='340' side='right'caption='[[7lna]]' scene=''> | + | <StructureSection load='7lna' size='340' side='right'caption='[[7lna]], [[Resolution|resolution]] 3.10Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7LNA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7LNA FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7lna]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Mesocricetus_auratus Mesocricetus auratus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7LNA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7LNA FirstGlance]. <br> |
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7lna FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7lna OCA], [https://pdbe.org/7lna PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7lna RCSB], [https://www.ebi.ac.uk/pdbsum/7lna PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7lna ProSAT]</span></td></tr> | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7lna FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7lna OCA], [https://pdbe.org/7lna PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7lna RCSB], [https://www.ebi.ac.uk/pdbsum/7lna PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7lna ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Disease == | ||
| + | [[https://www.uniprot.org/uniprot/PRIO_MESAU PRIO_MESAU]] Note=Found in high quantity in the brain of humans and animals infected with degenerative neurological diseases such as kuru, Creutzfeldt-Jakob disease (CJD), Gerstmann-Straussler syndrome (GSS), scrapie, bovine spongiform encephalopathy (BSE), transmissible mink encephalopathy (TME), etc. | ||
| + | == Function == | ||
| + | [[https://www.uniprot.org/uniprot/PRIO_MESAU PRIO_MESAU]] May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or ZN(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains (By similarity).<ref>PMID:19059915</ref> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Within the extensive range of self-propagating pathologic protein aggregates of mammals, prions are the most clearly infectious (e.g., approximately 10(9) lethal doses per milligram). The structures of such lethal assemblies of PrP molecules have been poorly understood. Here we report a near-atomic core structure of a brain-derived, fully infectious prion (263K strain). Cryo-electron microscopy showed amyloid fibrils assembled with parallel in-register intermolecular beta sheets. Each monomer provides one rung of the ordered fibril core, with N-linked glycans and glycolipid anchors projecting outward. Thus, single monomers form the templating surface for incoming monomers at fibril ends, where prion growth occurs. Comparison to another prion strain (aRML) revealed major differences in fibril morphology but, like 263K, an asymmetric fibril cross-section without paired protofilaments. These findings provide structural insights into prion propagation, strains, species barriers, and membrane pathogenesis. This structure also helps frame considerations of factors influencing the relative transmissibility of other pathologic amyloids. | ||
| + | |||
| + | High-resolution structure and strain comparison of infectious mammalian prions.,Kraus A, Hoyt F, Schwartz CL, Hansen B, Artikis E, Hughson AG, Raymond GJ, Race B, Baron GS, Caughey B Mol Cell. 2021 Aug 24. pii: S1097-2765(21)00651-1. doi:, 10.1016/j.molcel.2021.08.011. PMID:34433091<ref>PMID:34433091</ref> | ||
| + | |||
| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 7lna" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Artikis E]] | + | [[Category: Mesocricetus auratus]] |
| - | [[Category: Caughey B]] | + | [[Category: Artikis, E]] |
| - | [[Category: Hansen B]] | + | [[Category: Caughey, B]] |
| - | [[Category: Hoyt F]] | + | [[Category: Hansen, B]] |
| - | [[Category: Hughson | + | [[Category: Hoyt, F]] |
| - | [[Category: Kraus A]] | + | [[Category: Hughson, A G]] |
| - | [[Category: Race B]] | + | [[Category: Kraus, A]] |
| - | [[Category: Schwartz | + | [[Category: Race, B]] |
| + | [[Category: Schwartz, C L]] | ||
| + | [[Category: Glycosylated glycophophatidlyinositol-anchored amyloid]] | ||
| + | [[Category: Infectious mammalian prion]] | ||
| + | [[Category: Pirib]] | ||
| + | [[Category: Protein fibril]] | ||
| + | [[Category: Templating]] | ||
Revision as of 14:14, 17 November 2021
Infectious mammalian prion fibril (263K scrapie)
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