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1fqi

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[[Image:1fqi.gif|left|200px]]
[[Image:1fqi.gif|left|200px]]
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{{Structure
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{{STRUCTURE_1fqi| PDB=1fqi | SCENE= }}
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|RELATEDENTRY=[[1fqj|1FQJ]], [[1fqk|1FQK]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1fqi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fqi OCA], [http://www.ebi.ac.uk/pdbsum/1fqi PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1fqi RCSB]</span>
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'''RGS9 RGS DOMAIN'''
'''RGS9 RGS DOMAIN'''
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[[Category: Slep, K C.]]
[[Category: Slep, K C.]]
[[Category: Wensel, T G.]]
[[Category: Wensel, T G.]]
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[[Category: gap]]
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[[Category: Gap]]
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[[Category: phototransduction]]
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[[Category: Phototransduction]]
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[[Category: rg]]
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[[Category: Rg]]
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[[Category: rgs9]]
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[[Category: Rgs9]]
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[[Category: rod]]
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[[Category: Rod]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 16:38:45 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 20:28:15 2008''
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Revision as of 13:38, 2 May 2008

Image:1fqi.gif

Template:STRUCTURE 1fqi

RGS9 RGS DOMAIN


Overview

A multitude of heptahelical receptors use heterotrimeric G proteins to transduce signals to specific effector target molecules. The G protein transducin, Gt, couples photon-activated rhodopsin with the effector cyclic GMP phosophodiesterase (PDE) in the vertebrate phototransduction cascade. The interactions of the Gt alpha-subunit (alpha(t)) with the inhibitory PDE gamma-subunit (PDEgamma) are central to effector activation, and also enhance visual recovery in cooperation with the GTPase-activating protein regulator of G-protein signalling (RGS)-9 (refs 1-3). Here we describe the crystal structure at 2.0 A of rod transducin alpha x GDP x AlF4- in complex with the effector molecule PDEgamma and the GTPase-activating protein RGS9. In addition, we present the independently solved crystal structures of the RGS9 RGS domain both alone and in complex with alpha(t/i1) x GDP x AlF4-. These structures reveal insights into effector activation, synergistic GTPase acceleration, RGS9 specificity and RGS activity. Effector binding to a nucleotide-dependent site on alpha(t) sequesters PDEgamma residues implicated in PDE inhibition, and potentiates recruitment of RGS9 for hydrolytic transition state stabilization and concomitant signal termination.

About this Structure

1FQI is a Single protein structure of sequence from Bos taurus. Full crystallographic information is available from OCA.

Reference

Structural determinants for regulation of phosphodiesterase by a G protein at 2.0 A., Slep KC, Kercher MA, He W, Cowan CW, Wensel TG, Sigler PB, Nature. 2001 Feb 22;409(6823):1071-7. PMID:11234020 Page seeded by OCA on Fri May 2 16:38:45 2008

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