2xxz
From Proteopedia
(Difference between revisions)
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<StructureSection load='2xxz' size='340' side='right'caption='[[2xxz]], [[Resolution|resolution]] 1.80Å' scene=''> | <StructureSection load='2xxz' size='340' side='right'caption='[[2xxz]], [[Resolution|resolution]] 1.80Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
- | <table><tr><td colspan='2'>[[2xxz]] is a 2 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[2xxz]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XXZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XXZ FirstGlance]. <br> |
- | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=8XQ:8-HYDROXYQUINOLINE-5-CARBOXYLIC+ACID'>8XQ</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=8XQ:8-HYDROXYQUINOLINE-5-CARBOXYLIC+ACID'>8XQ</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr> |
- | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2xue|2xue]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2xue|2xue]]</div></td></tr> |
- | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xxz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xxz OCA], [https://pdbe.org/2xxz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xxz RCSB], [https://www.ebi.ac.uk/pdbsum/2xxz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xxz ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
- | [[ | + | [[https://www.uniprot.org/uniprot/KDM6B_HUMAN KDM6B_HUMAN]] Histone demethylase that specifically demethylates 'Lys-27' of histone H3, thereby playing a central role in histone code. Demethylates trimethylated and dimethylated H3 'Lys-27'. Plays a central role in regulation of posterior development, by regulating HOX gene expression. Involved in inflammatory response by participating in macrophage differentiation in case of inflammation by regulating gene expression and macrophage differentiation.<ref>PMID:17825402</ref> <ref>PMID:17851529</ref> |
==See Also== | ==See Also== |
Revision as of 14:56, 17 November 2021
Crystal structure of the human JMJD3 jumonji domain
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Categories: Human | Large Structures | Arrowsmith, C | Bountra, C | Burgess-Brown, N | Che, K H | Daniel, M | Edwards, A | Filippakopoulos, P | Krojer, T | Muniz, J R.C | Ng, S S | Oppermann, U | Savitsky, P | Tumber, A | Ugochukwu, E | Weigelt, J | Yue, W W | Chromatin modification | Histone demethylation | Oxidoreductase | Oxygenase