2y37

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<StructureSection load='2y37' size='340' side='right'caption='[[2y37]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
<StructureSection load='2y37' size='340' side='right'caption='[[2y37]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2y37]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y37 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2Y37 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2y37]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y37 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Y37 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=A54:2-[(1R)-3-AMINO-1-PHENYL-PROPOXY]-4-CHLORO-BENZONITRILE'>A54</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=H4B:5,6,7,8-TETRAHYDROBIOPTERIN'>H4B</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A54:2-[(1R)-3-AMINO-1-PHENYL-PROPOXY]-4-CHLORO-BENZONITRILE'>A54</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=H4B:5,6,7,8-TETRAHYDROBIOPTERIN'>H4B</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1vaf|1vaf]], [[1m9t|1m9t]], [[3nod|3nod]], [[1dwv|1dwv]], [[1m8e|1m8e]], [[1jwk|1jwk]], [[1qw4|1qw4]], [[2bhj|2bhj]], [[1r35|1r35]], [[1dd7|1dd7]], [[1qw5|1qw5]], [[1dwx|1dwx]], [[1noc|1noc]], [[1dww|1dww]], [[2nod|2nod]], [[1n2n|1n2n]], [[1qom|1qom]], [[1nod|1nod]], [[1nos|1nos]], [[1df1|1df1]], [[1m8i|1m8i]], [[2nos|2nos]], [[1m8d|1m8d]], [[1m8h|1m8h]], [[1jwj|1jwj]]</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1vaf|1vaf]], [[1m9t|1m9t]], [[3nod|3nod]], [[1dwv|1dwv]], [[1m8e|1m8e]], [[1jwk|1jwk]], [[1qw4|1qw4]], [[2bhj|2bhj]], [[1r35|1r35]], [[1dd7|1dd7]], [[1qw5|1qw5]], [[1dwx|1dwx]], [[1noc|1noc]], [[1dww|1dww]], [[2nod|2nod]], [[1n2n|1n2n]], [[1qom|1qom]], [[1nod|1nod]], [[1nos|1nos]], [[1df1|1df1]], [[1m8i|1m8i]], [[2nos|2nos]], [[1m8d|1m8d]], [[1m8h|1m8h]], [[1jwj|1jwj]]</div></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Nitric-oxide_synthase_(NADPH_dependent) Nitric-oxide synthase (NADPH dependent)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.13.39 1.14.13.39] </span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Nitric-oxide_synthase_(NADPH_dependent) Nitric-oxide synthase (NADPH dependent)], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.13.39 1.14.13.39] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2y37 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2y37 OCA], [http://pdbe.org/2y37 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2y37 RCSB], [http://www.ebi.ac.uk/pdbsum/2y37 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2y37 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2y37 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2y37 OCA], [https://pdbe.org/2y37 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2y37 RCSB], [https://www.ebi.ac.uk/pdbsum/2y37 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2y37 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/NOS2_MOUSE NOS2_MOUSE]] Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such COX2.<ref>PMID:16373578</ref>
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[[https://www.uniprot.org/uniprot/NOS2_MOUSE NOS2_MOUSE]] Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such COX2.<ref>PMID:16373578</ref>
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== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==

Revision as of 14:58, 17 November 2021

The discovery of novel, potent and highly selective inhibitors of inducible nitric oxide synthase (iNOS)

PDB ID 2y37

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