2y75

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<StructureSection load='2y75' size='340' side='right'caption='[[2y75]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
<StructureSection load='2y75' size='340' side='right'caption='[[2y75]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2y75]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/"vibrio_subtilis"_ehrenberg_1835 "vibrio subtilis" ehrenberg 1835]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y75 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2Y75 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2y75]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/"vibrio_subtilis"_ehrenberg_1835 "vibrio subtilis" ehrenberg 1835]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y75 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Y75 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2y75 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2y75 OCA], [http://pdbe.org/2y75 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2y75 RCSB], [http://www.ebi.ac.uk/pdbsum/2y75 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2y75 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2y75 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2y75 OCA], [https://pdbe.org/2y75 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2y75 RCSB], [https://www.ebi.ac.uk/pdbsum/2y75 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2y75 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/CYMR_BACSU CYMR_BACSU]] Master repressor of cysteine metabolism in B.subtilis. Controls the expression of genes involved either in cysteine synthesis from sulfide (cysK), sulfonates (ssu), or methionine (mccAB) or in cystine uptake (tcyP). Activity of CymR is positively regulated by CysK in response to cysteine availability. When cysteine is present, the pool of O-acetylserine (OAS) is low, which leads to the formation of a CymR-CysK complex and transcriptional repression of the CymR regulon occurs. In the absence of cysteine, the OAS pool is high and the CymR-CysK complex is mostly dissociated, leading to a faster dissociation of CymR from its DNA targets and the lifting of CymR-dependent repression.<ref>PMID:16513748</ref> <ref>PMID:18974048</ref>
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[[https://www.uniprot.org/uniprot/CYMR_BACSU CYMR_BACSU]] Master repressor of cysteine metabolism in B.subtilis. Controls the expression of genes involved either in cysteine synthesis from sulfide (cysK), sulfonates (ssu), or methionine (mccAB) or in cystine uptake (tcyP). Activity of CymR is positively regulated by CysK in response to cysteine availability. When cysteine is present, the pool of O-acetylserine (OAS) is low, which leads to the formation of a CymR-CysK complex and transcriptional repression of the CymR regulon occurs. In the absence of cysteine, the OAS pool is high and the CymR-CysK complex is mostly dissociated, leading to a faster dissociation of CymR from its DNA targets and the lifting of CymR-dependent repression.<ref>PMID:16513748</ref> <ref>PMID:18974048</ref>
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== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==

Revision as of 15:00, 17 November 2021

The Structure of CymR (YrzC) the Global Cysteine Regulator of B. subtilis

PDB ID 2y75

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