2y7j
From Proteopedia
(Difference between revisions)
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<StructureSection load='2y7j' size='340' side='right'caption='[[2y7j]], [[Resolution|resolution]] 2.50Å' scene=''> | <StructureSection load='2y7j' size='340' side='right'caption='[[2y7j]], [[Resolution|resolution]] 2.50Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2y7j]] is a 4 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[2y7j]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y7J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Y7J FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=B49:N-[2-(DIETHYLAMINO)ETHYL]-5-[(Z)-(5-FLUORO-2-OXO-1,2-DIHYDRO-3H-INDOL-3-YLIDENE)METHYL]-2,4-DIMETHYL-1H-PYRROLE-3-CARBOXAMIDE'>B49</scene></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=B49:N-[2-(DIETHYLAMINO)ETHYL]-5-[(Z)-(5-FLUORO-2-OXO-1,2-DIHYDRO-3H-INDOL-3-YLIDENE)METHYL]-2,4-DIMETHYL-1H-PYRROLE-3-CARBOXAMIDE'>B49</scene></td></tr> |
| - | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Phosphorylase_kinase Phosphorylase kinase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.19 2.7.11.19] </span></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2y7j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2y7j OCA], [https://pdbe.org/2y7j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2y7j RCSB], [https://www.ebi.ac.uk/pdbsum/2y7j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2y7j ProSAT]</span></td></tr> |
</table> | </table> | ||
== Disease == | == Disease == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/PHKG2_HUMAN PHKG2_HUMAN]] Glycogen storage disease due to liver phosphorylase kinase deficiency. The disease is caused by mutations affecting the gene represented in this entry. |
== Function == | == Function == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/PHKG2_HUMAN PHKG2_HUMAN]] Catalytic subunit of the phosphorylase b kinase (PHK), which mediates the neural and hormonal regulation of glycogen breakdown (glycogenolysis) by phosphorylating and thereby activating glycogen phosphorylase. May regulate glycogeneolysis in the testis. In vitro, phosphorylates PYGM (By similarity).<ref>PMID:10487978</ref> |
== References == | == References == | ||
<references/> | <references/> | ||
Revision as of 15:01, 17 November 2021
Structure of human phosphorylase kinase, gamma 2
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Categories: Human | Large Structures | Phosphorylase kinase | Arrowsmith, C H | Berridge, G | Bountra, C | Brenner, B | Burgess-Brown, N | Che, K H | Delft, F von | Edwards, A M | Elkins, J M | Fedorov, O | Knapp, S | Krojer, T | Muniz, J R.C | Rellos, P | Savitsky, P | Shrestha, A | Vollmar, M | Wang, J | Weigelt, J | Transferase
