1frt

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[[Image:1frt.gif|left|200px]]
[[Image:1frt.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1frt |SIZE=350|CAPTION= <scene name='initialview01'>1frt</scene>, resolution 4.5&Aring;
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The line below this paragraph, containing "STRUCTURE_1frt", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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or leave the SCENE parameter empty for the default display.
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|GENE= BETA-2-MICROGLOBULIN ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Rattus norvegicus])
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|DOMAIN=
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{{STRUCTURE_1frt| PDB=1frt | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1frt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1frt OCA], [http://www.ebi.ac.uk/pdbsum/1frt PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1frt RCSB]</span>
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}}
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'''CRYSTAL STRUCTURE OF THE COMPLEX OF RAT NEONATAL FC RECEPTOR WITH FC'''
'''CRYSTAL STRUCTURE OF THE COMPLEX OF RAT NEONATAL FC RECEPTOR WITH FC'''
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[[Category: Bjorkman, P J.]]
[[Category: Bjorkman, P J.]]
[[Category: Burmeister, W P.]]
[[Category: Burmeister, W P.]]
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[[Category: complex (receptor/immunoglobulin)]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 16:41:32 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 20:29:01 2008''
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Revision as of 13:41, 2 May 2008

Image:1frt.gif

Template:STRUCTURE 1frt

CRYSTAL STRUCTURE OF THE COMPLEX OF RAT NEONATAL FC RECEPTOR WITH FC


Overview

The neonatal Fc receptor (FcRn) transports maternal immunoglobulin G (IgG) to the bloodstream of the newborn. FcRn is structurally similar to class I major histocompatibility complex (MHC) molecules, despite differences in the ligands they bind (the Fc portion of IgG and antigenic peptides, respectively). A low-resolution crystal structure of the complex between FcRn and Fc localizes the binding site for Fc to the side of FcRn, distinct from the tops of the alpha 1 and alpha 2 domains which serve as the peptide and T-cell receptor binding sites in class I molecules. FcRn binds to Fc at the interface between the Fc CH2 and CH3 domains, which contains several histidine residues that could account for the sharply pH-dependent FcRn/IgG interaction. A dimer of FcRn heterodimers observed in the co-crystals and in the crystals of FcRn alone could be involved in binding Fc, correlating with the 2:1 binding stoichiometry between FcRn and IgG (ref. 4) and suggesting an unusual orientation of FcRn on the membrane.

About this Structure

1FRT is a Protein complex structure of sequences from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

Crystal structure of the complex of rat neonatal Fc receptor with Fc., Burmeister WP, Huber AH, Bjorkman PJ, Nature. 1994 Nov 24;372(6504):379-83. PMID:7969498 Page seeded by OCA on Fri May 2 16:41:32 2008

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