This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
2bve
From Proteopedia
(Difference between revisions)
| Line 3: | Line 3: | ||
<StructureSection load='2bve' size='340' side='right'caption='[[2bve]], [[Resolution|resolution]] 2.20Å' scene=''> | <StructureSection load='2bve' size='340' side='right'caption='[[2bve]], [[Resolution|resolution]] 2.20Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2bve]] is a 2 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[2bve]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BVE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BVE FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PH5:2-PHENYL-PROP5AC'>PH5</scene></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PH5:2-PHENYL-PROP5AC'>PH5</scene></td></tr> |
| - | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1od7|1od7]], [[1od9|1od9]], [[1oda|1oda]], [[1qfo|1qfo]], [[1qfp|1qfp]], [[1url|1url]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1od7|1od7]], [[1od9|1od9]], [[1oda|1oda]], [[1qfo|1qfo]], [[1qfp|1qfp]], [[1url|1url]]</div></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2bve FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bve OCA], [https://pdbe.org/2bve PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2bve RCSB], [https://www.ebi.ac.uk/pdbsum/2bve PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2bve ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/SN_MOUSE SN_MOUSE]] Acts as an endocytic receptor mediating clathrin dependent endocytosis. Macrophage-restricted adhesion molecule that mediates sialic-acid dependent binding to lymphocytes, including granulocytes, monocytes, natural killer cells, B-cells and CD8 T-cells (By similarity). Preferentially binds to alpha-2,3-linked sialic acid. Binds to SPN/CD43 on T-cells. May play a role in hematopoiesis. May act as a counter-receptor for CLEC10A in lymph node.<ref>PMID:15364954</ref> |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Revision as of 13:18, 24 November 2021
Structure of the N-terminal of Sialoadhesin in complex with 2-Phenyl- Prop5Ac
| |||||||||||
