2kfd
From Proteopedia
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<StructureSection load='2kfd' size='340' side='right'caption='[[2kfd]], [[NMR_Ensembles_of_Models | 15 NMR models]]' scene=''> | <StructureSection load='2kfd' size='340' side='right'caption='[[2kfd]], [[NMR_Ensembles_of_Models | 15 NMR models]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2kfd]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[2kfd]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KFD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KFD FirstGlance]. <br> |
| - | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PRP40, YKL012W, YKL165 ([ | + | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PRP40, YKL012W, YKL165 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824])</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kfd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kfd OCA], [https://pdbe.org/2kfd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kfd RCSB], [https://www.ebi.ac.uk/pdbsum/2kfd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kfd ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/PRP40_YEAST PRP40_YEAST]] Required for pre-spliceosome formation, which is the first step of pre-mRNA splicing. This protein is associated with snRNP U1. Two commitment complexes, CC1 and CC2, have been defined in yeast. CC1 is a basal complex dependent only on the 5' splice site. CC2 is a complex of lower mobility and is dependent on a branchpoint as well as a 5' splice site region. This protein is involved in CC2 formation where it binds to the branchpoint binding protein MSL5, bridging the U1 snRNP-associated 5' splice site and the MSL5-associated branch point 3' intron splice site.<ref>PMID:9150140</ref> <ref>PMID:10978320</ref> <ref>PMID:15020406</ref> |
==See Also== | ==See Also== | ||
Revision as of 13:31, 24 November 2021
Prp40 FF4 domain
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