2yrp

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
==Solution structure of the TIG domain from Human Nuclear factor of activated T-cells, cytoplasmic 4==
==Solution structure of the TIG domain from Human Nuclear factor of activated T-cells, cytoplasmic 4==
-
<StructureSection load='2yrp' size='340' side='right' caption='[[2yrp]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
+
<StructureSection load='2yrp' size='340' side='right'caption='[[2yrp]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[2yrp]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YRP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2YRP FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[2yrp]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YRP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YRP FirstGlance]. <br>
-
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">NFATC4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
+
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">NFATC4 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2yrp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yrp OCA], [http://pdbe.org/2yrp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2yrp RCSB], [http://www.ebi.ac.uk/pdbsum/2yrp PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2yrp ProSAT], [http://www.topsan.org/Proteins/RSGI/2yrp TOPSAN]</span></td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2yrp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yrp OCA], [https://pdbe.org/2yrp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2yrp RCSB], [https://www.ebi.ac.uk/pdbsum/2yrp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2yrp ProSAT], [https://www.topsan.org/Proteins/RSGI/2yrp TOPSAN]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
-
[[http://www.uniprot.org/uniprot/NFAC4_HUMAN NFAC4_HUMAN]] Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 and IL-4. Transcriptionally repressed by estrogen receptors; this inhibition is further enhanced by estrogen. Increases the transcriptional activity of PPARG and has a direct role in adipocyte differentiation. May play an important role in myotube differentiation. May play a critical role in cardiac development and hypertrophy. May play a role in deafferentation-induced apoptosis of sensory neurons.<ref>PMID:7749981</ref> <ref>PMID:11997522</ref> <ref>PMID:17213202</ref> <ref>PMID:18668201</ref>
+
[[https://www.uniprot.org/uniprot/NFAC4_HUMAN NFAC4_HUMAN]] Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 and IL-4. Transcriptionally repressed by estrogen receptors; this inhibition is further enhanced by estrogen. Increases the transcriptional activity of PPARG and has a direct role in adipocyte differentiation. May play an important role in myotube differentiation. May play a critical role in cardiac development and hypertrophy. May play a role in deafferentation-induced apoptosis of sensory neurons.<ref>PMID:7749981</ref> <ref>PMID:11997522</ref> <ref>PMID:17213202</ref> <ref>PMID:18668201</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Line 24: Line 24:
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Human]]
 +
[[Category: Large Structures]]
[[Category: Harada, T]]
[[Category: Harada, T]]
[[Category: Kigawa, T]]
[[Category: Kigawa, T]]

Revision as of 13:36, 24 November 2021

Solution structure of the TIG domain from Human Nuclear factor of activated T-cells, cytoplasmic 4

PDB ID 2yrp

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2yrp"
Personal tools