Nonstructural protein 3D structures

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Line 6: Line 6:
*Nonstructural protein
*Nonstructural protein
-
**[[3o9q]], [[4opa]], [[4oph]] – IvNS1 (mutant) – Influenza virus<br />
+
**[[3o9q]], [[4opa]], [[4oph]], [[6nrl]], [[6o01]], [[6oqe]] – IvNS1 (mutant) – Influenza virus<br />
**[[3o9r]], [[3o9s]], [[3o9t]], [[3o9u]], [[3f5t]] – IvNS1<br />
**[[3o9r]], [[3o9s]], [[3o9t]], [[3o9u]], [[3f5t]] – IvNS1<br />
-
**[[3m8a]], [[2z0a]], [[1xeq]], [[1ail]] – IvNS1 RNA-binding domain<br />
+
**[[3m8a]], [[2z0a]], [[1xeq]], [[1ail]], [[6sw8]] – IvNS1 RNA-binding domain 2-73<br />
 +
**[[1ns1]] - IvNS1 RNA-binding domain - NMR<br />
**[[3p31]] – IvNS1 C terminal effector domain<br />
**[[3p31]] – IvNS1 C terminal effector domain<br />
-
**[[3p38]], [[3p39]] – IvNS1 C terminal effector domain (mutant)<br />
+
**[[3p38]], [[3p39]] – IvNS1 C terminal effector domain (mutant) <br />
-
**[[1ns1]] - IvNS1 RNA-binding domain - NMR<br />
+
**[[3m5r]], [[2gx9]] - IvNS1 effector domain<br />
**[[3m5r]], [[2gx9]] - IvNS1 effector domain<br />
 +
**[[6nu0]] - IvNS1 effector domain 1-230 – NMR<br />
 +
**[[6dgn]] - IvNS1 effector domain (mutant) 86-205<br />
**[[1pd3]] – IvNS2 M1-binding domain<br />
**[[1pd3]] – IvNS2 M1-binding domain<br />
**[[3l6p]], [[3lkw]] – DvNS2B/3 protease domain (mutant) – Dengue virus<br />
**[[3l6p]], [[3lkw]] – DvNS2B/3 protease domain (mutant) – Dengue virus<br />
-
**[[4r05]] – DvNS5 residues 2491-2752 <br />
+
**[[2o1]]j – RvNSP4 diarrhea-inducing domain – Human rotavirus<br />
-
**[[2o1j]] – RvNSP4 diarrhea-inducing domain – human rotavirus<br />
+
**[[2gu0]], [[6auk]], [[6cy9]], [[7kpo]], [[7kpp]] – RvNS2<br />
-
**[[2gu0]] – RvNS2<br />
+
**[[5y2h]], [[5y2j]], [[5y9r]] – RvNSP4 diarrhea-inducing domain – bovine rotavirus<br />
-
**[[5y2h]], [[5y2j]], [[5y9r]] – NSP4 diarrhea-inducing domain – bovine rotavirus<br />
+
**[[2ajj]], [[2ajm]], [[2ajn]], [[2ajo]] – NS5A membrane-anchor domain – bovine viral diarrhea virus – NMR<br />
**[[2ajj]], [[2ajm]], [[2ajn]], [[2ajo]] – NS5A membrane-anchor domain – bovine viral diarrhea virus – NMR<br />
-
**[[1fw5]] – NSP1 membrane-binding domain – Semliki forest virus – NMR<br />
+
**[[1fw5]] – NS1 membrane-binding domain – Semliki forest virus – NMR<br />
-
**[[5vj2]] – NS1 – respiratory syncytial virus<br />
+
**[[5vj2]] – HrsvNS1 – Human respiratory syncytial virus<br />
 +
**[[7ldk]] – HrsvNS2<br />
**[[5i65]] – NS ORF1A – porcine reproductive and respiratory syndrome virus<br />
**[[5i65]] – NS ORF1A – porcine reproductive and respiratory syndrome virus<br />
 +
**[[6lpa]] – pcvNS1 – porcine corona virus<br />
 +
**[[6ln0]] – pcvNS3 <br />
 +
**[[6mwm]] – NS3 – bat corona virus - NMR<br />
**[[1qol]] – NSP20A (mutant) - Foot-and-mouth disease virus<br />
**[[1qol]] – NSP20A (mutant) - Foot-and-mouth disease virus<br />
**[[1nhu]] – HvNS5B RNA-dependent RNA polymerase residues 2420-2989 – Hepatitis C virus<br />
**[[1nhu]] – HvNS5B RNA-dependent RNA polymerase residues 2420-2989 – Hepatitis C virus<br />
**[[1r7c]], [[1r7d]], [[1r7e]], [[1r7f]], [[1r7g]] - HvNS5A membrane-anchor domain - NMR<br />
**[[1r7c]], [[1r7d]], [[1r7e]], [[1r7f]], [[1r7g]] - HvNS5A membrane-anchor domain - NMR<br />
**[[2gdt]], [[2hsx]] – SvNS1 (mutant) – Sars coronavirus – NMR<br />
**[[2gdt]], [[2hsx]] – SvNS1 (mutant) – Sars coronavirus – NMR<br />
-
**[[7jtl]] – Sv2NS8 residues 18-121 – Sars-cov-2<br />
+
**]]2l8k]] – NS7 residues 1454-1575 – Arterivirus - NMR<br />
-
**[[7k3n]], [[7k7p]] – Sv2NS1<br />
+
**[[3mtv]] – PrrsvNS1 residues 181-383 – PRRS virus <br />
-
**[[6w9c]] – Sv2NS3 residues 1564-1878<br />
+
**[[6jdr]], [[6jds]], [[6jdu]] – PrrsvNS10 <br />
-
**[[6wc1]], [[6wrb]], [[6wxd]] – Sv2NS9 residues 4141-4235<br />
+
-
**[[6zct]], [[6zpe]] – Sv2NS10 residues 4263-4384<br />
+
-
**[[2jzd]], [[2jze]], [[2jzf]], [[2rnk]] – SvNS3 residues 527-651 – NMR<br />
+
-
**[[2kaf]] - SvNS3 residues 1473-1532 – NMR <br />
+
-
**[[2kys]] – SvNS7 – NMR<br />
+
-
**[[2l8k]] – NS7 residues 1454-1575 – NMR<br />
+
-
**[[3mtv]] – NS1 residues 181-383 – PRRS virus <br />
+
**[[3zfn]], [[3zfo]], [[3zfq]], [[3zfp]], [[3zfr]], [[3zft]], [[3zfu]] – Npro (mutant) – Pestivirus<br />
**[[3zfn]], [[3zfo]], [[3zfq]], [[3zfp]], [[3zfr]], [[3zft]], [[3zfu]] – Npro (mutant) – Pestivirus<br />
 +
**[[4r05]] – DvNS5 residues 2491-2752 <br />
**[[4x2z]] – NS3 residues 1174-1483 – Avian infectious bronchitis virus<br />
**[[4x2z]] – NS3 residues 1174-1483 – Avian infectious bronchitis virus<br />
 +
**[[5rhl]], [[6mh3]] – ZvNS3 helicase domain 1681-2115 – Zika virus<br />
 +
**[[4cbg]], [[4cbh]], [[4cbl]], [[4cbm]] – NS3 – Swine fever virus<br />
 +
**[[2hwk]] – NS2 – Venzuelan equine encephalitis virus<br />
 +
**[[6lp9]] – fipvNSP1 – Feline infectious peritonitis virus<br />
 +
**[[3ub0]] – fipvNSP6 + NSP7 <br />
 +
**[[6ivc]] – tgvNSP1 – transmissible gastroenteritis virus<br />
 +
**[[6ivd]] – tgvNSP1 (mutant)<br />
 +
**[[6n9y]] – NS1 – Bluetongue virus<br />
 +
**[[6vdo]] – HcvNS3 (mutant) – Hepacivirus C<br />
 +
**[[7ay4]], [[7jno]] – NS3 helicase domain – Tick-borne encephalitis virus<br />
*Nonstructural protein complex
*Nonstructural protein complex
-
**[[2xbm]] – DvNS5 methyltransferase domain + RNA<br />
+
**[[6weq]], [[6wer]], [[7bsc]] – DvNS1 + antibody<br />
 +
**[[7k93]] – DvNS1 + scFv<br />
 +
**[[2xbm]] – DvNS5 methyltransferase domain + RNA <br />
**[[3p8z]] - DvNS5 methyltransferase domain + SAH + inhibitor<br />
**[[3p8z]] - DvNS5 methyltransferase domain + SAH + inhibitor<br />
**[[5cuq]] - DvNS5 methyltransferase domain + inhibitor<br />
**[[5cuq]] - DvNS5 methyltransferase domain + inhibitor<br />
Line 48: Line 59:
**[[2hye]] – SvNSV + DNA damage-binding protein + cullin-4A + ring-box protein – Simian virus 5<br />
**[[2hye]] – SvNSV + DNA damage-binding protein + cullin-4A + ring-box protein – Simian virus 5<br />
**[[2b5l]] - SvNSV + DNA damage-binding protein<br />
**[[2b5l]] - SvNSV + DNA damage-binding protein<br />
-
**[[1nhv]], [[1nhu]] – HvNS5B RNA-dependent RNA polymerase residues 2420-2989 + inhibitor<br />
+
**[[1nhv]] – HvNS5B RNA-dependent RNA polymerase residues 2420-2989 + inhibitor<br />
**[[1dxp]], [[1dy8]], [[1dy9]], [[1w3c]] – HvNS4A + HvHelicase NS3<br />
**[[1dxp]], [[1dy8]], [[1dy9]], [[1w3c]] – HvNS4A + HvHelicase NS3<br />
**[[4k8b]] - HvNS4A + HvProtease NS3 + inhibitor<br />
**[[4k8b]] - HvNS4A + HvProtease NS3 + inhibitor<br />
**[[4a1t]], [[4a1x]] - HvNS4A + peptide inhibitor<br />
**[[4a1t]], [[4a1x]] - HvNS4A + peptide inhibitor<br />
-
**[[3phe]] – HvNS5B + quinolone derivative<br />
+
**[[3phe]]– HvNS5B + quinolone derivative<br />
-
**[[3ub0]] – NSP6 + NSP7 – Feline infectious peritonitis virus<br />
+
**[[6w4g]] – HvNS5B 2421-2981 + inhibitor<br />
**[[1knz]] – RvNSP34 N terminal + mRNA<br />
**[[1knz]] – RvNSP34 N terminal + mRNA<br />
**[[1lj2]] – RvNSP34 C terminal + eukaryotic protein synthesis initiation factor peptide<br />
**[[1lj2]] – RvNSP34 C terminal + eukaryotic protein synthesis initiation factor peptide<br />
**[[4r8r]] – DvNS5 residues 2491-2752 + adenosyl-Met<br />
**[[4r8r]] – DvNS5 residues 2491-2752 + adenosyl-Met<br />
**[[4r8s]] – DvNS5 residues 2491-2752 + sinefungin<br />
**[[4r8s]] – DvNS5 residues 2491-2752 + sinefungin<br />
-
**[[6ux2]] – NS5 residues 2789-3419 + P113 – Zika virus<br />
+
**[[6ux2]] – ZvNS5 residues 2789-3419 + P113 <br />
 +
**[[5rhg]], [[5rhh]], [[5rhi]], [[5rhj]], [[5rhk]], [[5rhl]], [[5rhm]], [[5rho]], [[5rhp]], [[5rhq]], [[5rhr]], [[5rhs]], [[5rht]], [[5rhu]], [[5rhv]], [[5rhw]], [[5rhx]] – ZvNS3 + inhibitor <br />
 +
**[[6jpw]] – ZvNS3 + NS2B + peptide <br />
 +
**[[6rwz]], [[6s0j]] – ZvNS3 + ADP<br />
 +
**[[6wcz]] – ZvNS5 + hSTAT2<br />
 +
**[[6i7p]] – ZvNS5 + SAH<br />
 +
**[[6jim]] – NS2 + RNA – Chicungunya virus<br />
 +
**[[6usm]] – NS1 + MBP – Human parvovirus<br />
 +
**[6sx0]], [[6zlc]] – IvNS1 RNA-binding domain + RNA<br />
 +
**[[6sx2]] – IvNS1 RNA-binding domain (mutant) + RNA<br />
 +
**[[6e5u]] – IvNS1 + NXF1 + NXT1<br />
 +
**[[6mvo]] – HcvNS5B + inhibitor<br />
 +
**[[6qsn]] – NS5A + SAH – yellow fever virus<br />
-
*Nonstructural protein complex from SARS CoV-2
+
*Nonstructural protein NS3 from SARS CoV-2; Domain 1564-1878 (papain-like protease), [[3241-3546 (3C-like proteinase) see [[Virus protease 3D structures]]
 +
 
 +
**[[2jzd[[, [[2jze]], [[2jzf]], [[2rnk]] – SvNS3 residues 527-651 – NMR<br />
 +
**[[7kag]] – Sv2NS3 Ubl1 domain 819-929<br />
 +
**[[6vxs]], [[6wcf]], [[6wen]], [[6wey]], [[6ywk]], [[6ywm]], [[7kg3]], [[7kqo]], [[7kqw]], [[7kr0]], [[7kr1]] – Sv2NS3 macrodomain 1025-1191<br />
 +
**[[2kaf]] - SvNS3 residues 1473-1532 – NMR <br />
 +
**[[7lgo]] – Sv2NS3 NAB domain 1907-2021<br />
 +
**[[7rqg]] – Sv2NS3 Y3 domain 2662-2763<br />
 +
**[[7kxb]], [[7lg7]] – Sv2NS3 macrodomain + inhibitor<br />
 +
**[[6w02]], [[6woj]], [[6ywl]], [[7bf5]], [[7c33]], [[7cz4]], [[7kqp]] – Sv2NS3 macrodomain + ADP-ribose<br />
 +
**[[6w6y]], [[7nme]] – Sv2NS3 macrodomain + cyclic AMP<br />**
 +
**[[7bf4]] – Sv2NS3 macrodomain + GMP<br />
 +
**[[7bf3]] – Sv2NS3 macrodomain + adenosine<br />
 +
**[[7bf6]] – Sv2NS3 macrodomain + drug<br />
 +
**[[6yxj]] – Sv2NS3 macrodomain II 1207-1344 + Paip1<br />
 +
 
 +
*Other nonstructural protein from SARS CoV-2
**[[6zlw]], [[6zoj]], [[6zok]], [[6zol]], [[7k5i]] – Sv2NS1 in human 40S ribosome – Cryo EM<br />
**[[6zlw]], [[6zoj]], [[6zok]], [[6zol]], [[7k5i]] – Sv2NS1 in human 40S ribosome – Cryo EM<br />
Line 67: Line 106:
**[[6zm7]], [[6zme]], [[6zmi]], [[6zmo]] – Sv2NS1 in human 80S ribosome – Cryo EM<br />
**[[6zm7]], [[6zme]], [[6zmi]], [[6zmo]] – Sv2NS1 in human 80S ribosome – Cryo EM<br />
**[[7jqb]], [[7jqc]] – Sv2NS1 in rabbit 40S ribosome – Cryo EM<br />
**[[7jqb]], [[7jqc]] – Sv2NS1 in rabbit 40S ribosome – Cryo EM<br />
-
**[[5f22]], [[6m5i]], [[6wiq]], [[6wqd]], [[6wtc]], [[6xip]], [[6yhu]], [[7jlt]] – Sv2NS7 residues 3860-3930 + Sv2NS8 residues 4018-4134<br />
+
**[[7opl]] – Sv2NS1 13-127 + DNA polymerase + DNA primase – Cryo EM<br />
-
**[[6xqb]] – Sv2NS7 residues 3860-3930 + Sv2NS8 residues 4018-4134 + RNA – Cryo EM<br />
+
**[[7k7p]] – Sv2NS1 1-180<br />
-
**[[7c2k]] – Sv2NS7 residues 3860-3930 + Sv2NS8 residues 4018-4134 + Sv2NS12 residues 4393-5324 + RNA<br />
+
**[[7msw]], [[7msx]] – Sv2NS2 – Cryo EM<br />
-
**[[6m71]], [[7btf]], [[7bv1]], [[7bw4]] – Sv2NS7 residues 3860-3930 + Sv2NS8 residues 4018-4134 + Sv2NS12 residues 4393-5324 – Cryo EM<br />
+
**[[7exm]] – Sv2NS2 181-456<br />
-
**[[6yyt]], [[7bzf]] – Sv2NS7 residues 3860-3930 + Sv2NS8 residues 4018-4134 + Sv2NS12 residues 4393-5324 + RNA – Cryo EM<br />
+
**[[2kys]] – Sv2NS7 3837-3919 – NMR<br />
-
**[[7aap]], [[7b3b]], [[7b3c]], [[7bv2]], [[7ctt]] – Sv2NS7 residues 3860-3930 + Sv2NS8 residues 4018-4134 + Sv2NS12 residues 4393-5324 + RNA + drug – Cryo EM<br />
+
**[[7jtl]] – Sv2NS8 residues 18-121 <br />
 +
**[[6w4b]], [[6wc1]], [[6wrb]], [[6wxd]] – Sv2NS9 residues 4141-4235<br />
 +
**[[6zct]], [[6zpe]], [[7nts]] – Sv2NS10 residues 4263-4384<br />
 +
**[[7orr]], [[7oru]], [[7orv]], [[7orw]] – Sv2NS10 residues 4263-4384 + imidazole derivative<br />
 +
**[[6z6i]] – Sv2NS10 residues 1024-1197 + ADP derivative<br />
 +
**[[5f22]], [[6m5i]], [[6wiq]], [[6wqd]], [[6wtc]], [[6xip]], [[6yhu]], [[7dcd]], [[7jlt]] – Sv2NS7 residues 3860-3930 + Sv2NS8 residues 4018-4134<br />
 +
**[[6m71]], [[7btf]], [[7bv1]], [[7bw4]], [[7d4f]] – Sv2NS7 residues 3860-3930 + Sv2NS8 residues 4018-4134 + Sv2NS12 residues 4393-5324 – Cryo EM<br />
 +
**[[6nur]], [[6nus]] – Sv2NS8 residues 4018-4134 + Sv2NS12 residues 4393-5324 – Cryo EM<br />
 +
**[[5rob]], [[6jyt]], [[6zsl]], [[7nio]] – SvNS13 <br />
 +
**[[7diy]] – Sv2NS14 residues 5926-6214 + Sv2NS10 residues 4254-4392<br />
 +
**[[6vww]], [[6w01]], [[6xdh]], [[7kf4]] – Sv2NS15 residues 6453-6798<br />
 +
**[[6w4h]] – Sv2NS16 residues 6799-7096 + Sv2NS10 residues 4254-4392<br />
 +
 
 +
*Other nonstructural protein from SARS CoV-2 complexes
 +
 
 +
**[[7ozu]], [[7ozv]] – Sv2NS7 residues 3860-3930 + Sv2NS8 residues 4018-4134 + RNA + replicase polyprotein – Cryo EM<br />
 +
**[[6xqb]], [[6yyt]], [[7bzf]], [[7c2k]], [[7cyq]], [[[7dte]], [7krn]], [[7kro]], [[7krp]], [[7l1f]], [[7oyg]] – Sv2NS7 residues 3860-3930 + Sv2NS8 residues 4018-4134 + Sv2NS12 residues 4393-5324 + RNA – Cryo EM<br />
 +
**[[7aap]], [[7b3b]], [[7b3c]], [[7bv2]], [[7ctt]], [[7dfg]], [[7dfh]] – Sv2NS7 residues 3860-3930 + Sv2NS8 residues 4018-4134 + Sv2NS12 residues 4393-5324 + RNA + drug – Cryo EM<br />
**[[7b3d]] – Sv2NS7 residues 3860-3930 + Sv2NS8 residues 4018-4134 + Sv2NS12 residues 4393-5324 + RNA + AMP – Cryo EM<br />
**[[7b3d]] – Sv2NS7 residues 3860-3930 + Sv2NS8 residues 4018-4134 + Sv2NS12 residues 4393-5324 + RNA + AMP – Cryo EM<br />
 +
**[[7rdx]], [[7rdz]], [[7re3]] – Sv2NS7 residues 3860-3930 + Sv2NS8 residues 4018-4134 + Sv2NS12 residues 4393-5324 + RNA + ADP + helicase – Cryo EM<br />
**[[6xez]], [[7cxm]], [[7cxn]], [[7cyq]] – Sv2NS7 residues 3860-3930 + Sv2NS8 residues 4018-4134 + Sv2NS12 residues 4393-5324 + Sv2NS13 residues 5325-5925 + RNA – Cryo EM<br />
**[[6xez]], [[7cxm]], [[7cxn]], [[7cyq]] – Sv2NS7 residues 3860-3930 + Sv2NS8 residues 4018-4134 + Sv2NS12 residues 4393-5324 + Sv2NS13 residues 5325-5925 + RNA – Cryo EM<br />
-
**[[6w4h]] – Sv2NS16 residues 6799-7096 + Sv2NS10 residues 4254-4392<br />
+
**[[7n3k]] – Sv2NS9 residues 4141-4253 + drug<br />
 +
**[[7kri]] – Sv2NS9 residues 4141-4253 + pyrimidine derivative<br />
 +
**[[7mc5]], [[7mc6]] – Sv2NS10 residues 4254-4392 + proofreading exoribonuclease<br />
 +
**[[7n0b]], [[7n0c]], [[7n0d]] – Sv2NS10 residues 4254-4392 + proofreading exoribonuclease + RNA – Cryo EM<br />
 +
**[[5rl6]], [[5rl7]], [[5rl8]], [[5rl9]], [[5rlc]], [[5rld]], [[5rle]], [[5rlf]], [[5rlg]], [[5rlh]], [[5rli]], [[5rlj]], [[5rlk]], [[5rll]], [[5rlm]], [[5rln]], [[5rlo]], [[5rlp]], [[5rlq]], [[5rlr]], [[5rls]], [[5rlt]], [[5rlu]], [[5rlv]], [[5rlw]], [[5rly]], [[5rlz]], [[5rm0]], [[5rm1]], [[5rm2]], [[5rm3]], [[5rm4]], [[5rm5]], [[5rm6]], [[5rm7]], [[5rm8]], [[5rm9]], [[5rma]], [[5rmb]], [[5rmc]], [[5rmd]], [[5rme]], [[5rmf]], [[5rmg]], [[5rmh]], [[5rmi]], [[5rmj]], [[5rmk]] [[5rml]], [[5rmm]], [[7nng]] – SvNS13 + inhibitor<br />
 +
**[[7nn0]] – SvNS13 + AMPPNP<br />
 +
**[6wlc]], [[6x4i]], [[7k1l]] – Sv2NS15 residues 6453-6798 + uridine derivative<br />
 +
**[[6wxc]] – Sv2NS15 residues 6453-6798 + drug<br />
**[[6w61]], [[6w75]], [[6wvn]], [[6xkm]], [[7bq7]], [[7c2i]], [[7c2j]], [[7jpe]], [[7koa]] – Sv2NS16 residues 6799-7096 + Sv2NS10 residues 4254-4392 + SAM<br />
**[[6w61]], [[6w75]], [[6wvn]], [[6xkm]], [[7bq7]], [[7c2i]], [[7c2j]], [[7jpe]], [[7koa]] – Sv2NS16 residues 6799-7096 + Sv2NS10 residues 4254-4392 + SAM<br />
-
**[[6wjt]], [[6wq3]], [[6wrz]], [[7jhe]] – Sv2NS16 residues 6799-7096 + Sv2NS10 residues 4254-4392 + SAH<br />
+
**[[6wjt]], [[6wq3]], [[6wrz]], [[7jhe]], [[7lw3]], [[7lw4]] – Sv2NS16 residues 6799-7096 + Sv2NS10 residues 4254-4392 + SAH<br />
**[[7jib]] – Sv2NS16 residues 6799-7096 + Sv2NS10 residues 4254-4392 + SAH + SAM<br />
**[[7jib]] – Sv2NS16 residues 6799-7096 + Sv2NS10 residues 4254-4392 + SAH + SAM<br />
**[[7jyy]] – Sv2NS16 residues 6799-7096 + Sv2NS10 residues 4254-4392 + SAM + RNA<br />
**[[7jyy]] – Sv2NS16 residues 6799-7096 + Sv2NS10 residues 4254-4392 + SAM + RNA<br />
-
**[[6kws]] – Sv2NS16 residues 6799-7096 + Sv2NS10 residues 4254-4392 + SAM + GpppA<br />
+
**[[6wks]] – Sv2NS16 residues 6799-7096 + Sv2NS10 residues 4254-4392 + SAM + GpppA<br />
**[[7jz0]], [[7l6r]], [[7l6t]] – Sv2NS16 residues 6799-7096 + Sv2NS10 residues 4254-4392 + SAH + RNA<br />
**[[7jz0]], [[7l6r]], [[7l6t]] – Sv2NS16 residues 6799-7096 + Sv2NS10 residues 4254-4392 + SAH + RNA<br />
**[[6wkq]], [[6yz1]] – Sv2NS16 residues 6799-7096 + Sv2NS10 residues 4254-4392 + sinefungin<br />
**[[6wkq]], [[6yz1]] – Sv2NS16 residues 6799-7096 + Sv2NS10 residues 4254-4392 + sinefungin<br />
**[[6yyt]] – Sv2NS12 residues 4393-5324 + Sv2NS8 residues 3943-4140 + Sv2NS7 residues 3860-3942 + RNA<br />
**[[6yyt]] – Sv2NS12 residues 4393-5324 + Sv2NS8 residues 3943-4140 + Sv2NS7 residues 3860-3942 + RNA<br />
 +
}}
}}
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 09:10, 28 November 2021

3D Structures of Nonstructural protein

Updated on 28-November-2021 {{#tree:id=OrganizedByTopic|openlevels=0|

  • Nonstructural protein
    • 3o9q, 4opa, 4oph, 6nrl, 6o01, 6oqe – IvNS1 (mutant) – Influenza virus
    • 3o9r, 3o9s, 3o9t, 3o9u, 3f5t – IvNS1
    • 3m8a, 2z0a, 1xeq, 1ail, 6sw8 – IvNS1 RNA-binding domain 2-73
    • 1ns1 - IvNS1 RNA-binding domain - NMR
    • 3p31 – IvNS1 C terminal effector domain
    • 3p38, 3p39 – IvNS1 C terminal effector domain (mutant)
    • 3m5r, 2gx9 - IvNS1 effector domain
    • 6nu0 - IvNS1 effector domain 1-230 – NMR
    • 6dgn - IvNS1 effector domain (mutant) 86-205
    • 1pd3 – IvNS2 M1-binding domain
    • 3l6p, 3lkw – DvNS2B/3 protease domain (mutant) – Dengue virus
    • 2o1j – RvNSP4 diarrhea-inducing domain – Human rotavirus
    • 2gu0, 6auk, 6cy9, 7kpo, 7kpp – RvNS2
    • 5y2h, 5y2j, 5y9r – RvNSP4 diarrhea-inducing domain – bovine rotavirus
    • 2ajj, 2ajm, 2ajn, 2ajo – NS5A membrane-anchor domain – bovine viral diarrhea virus – NMR
    • 1fw5 – NS1 membrane-binding domain – Semliki forest virus – NMR
    • 5vj2 – HrsvNS1 – Human respiratory syncytial virus
    • 7ldk – HrsvNS2
    • 5i65 – NS ORF1A – porcine reproductive and respiratory syndrome virus
    • 6lpa – pcvNS1 – porcine corona virus
    • 6ln0 – pcvNS3
    • 6mwm – NS3 – bat corona virus - NMR
    • 1qol – NSP20A (mutant) - Foot-and-mouth disease virus
    • 1nhu – HvNS5B RNA-dependent RNA polymerase residues 2420-2989 – Hepatitis C virus
    • 1r7c, 1r7d, 1r7e, 1r7f, 1r7g - HvNS5A membrane-anchor domain - NMR
    • 2gdt, 2hsx – SvNS1 (mutant) – Sars coronavirus – NMR
    • ]]2l8k]] – NS7 residues 1454-1575 – Arterivirus - NMR
    • 3mtv – PrrsvNS1 residues 181-383 – PRRS virus
    • 6jdr, 6jds, 6jdu – PrrsvNS10
    • 3zfn, 3zfo, 3zfq, 3zfp, 3zfr, 3zft, 3zfu – Npro (mutant) – Pestivirus
    • 4r05 – DvNS5 residues 2491-2752
    • 4x2z – NS3 residues 1174-1483 – Avian infectious bronchitis virus
    • 5rhl, 6mh3 – ZvNS3 helicase domain 1681-2115 – Zika virus
    • 4cbg, 4cbh, 4cbl, 4cbm – NS3 – Swine fever virus
    • 2hwk – NS2 – Venzuelan equine encephalitis virus
    • 6lp9 – fipvNSP1 – Feline infectious peritonitis virus
    • 3ub0 – fipvNSP6 + NSP7
    • 6ivc – tgvNSP1 – transmissible gastroenteritis virus
    • 6ivd – tgvNSP1 (mutant)
    • 6n9y – NS1 – Bluetongue virus
    • 6vdo – HcvNS3 (mutant) – Hepacivirus C
    • 7ay4, 7jno – NS3 helicase domain – Tick-borne encephalitis virus
  • Nonstructural protein complex
    • 6weq, 6wer, 7bsc – DvNS1 + antibody
    • 7k93 – DvNS1 + scFv
    • 2xbm – DvNS5 methyltransferase domain + RNA
    • 3p8z - DvNS5 methyltransferase domain + SAH + inhibitor
    • 5cuq - DvNS5 methyltransferase domain + inhibitor
    • 5fc8 - DvNS5 C-terminal + importin
    • 2hye – SvNSV + DNA damage-binding protein + cullin-4A + ring-box protein – Simian virus 5
    • 2b5l - SvNSV + DNA damage-binding protein
    • 1nhv – HvNS5B RNA-dependent RNA polymerase residues 2420-2989 + inhibitor
    • 1dxp, 1dy8, 1dy9, 1w3c – HvNS4A + HvHelicase NS3
    • 4k8b - HvNS4A + HvProtease NS3 + inhibitor
    • 4a1t, 4a1x - HvNS4A + peptide inhibitor
    • 3phe– HvNS5B + quinolone derivative
    • 6w4g – HvNS5B 2421-2981 + inhibitor
    • 1knz – RvNSP34 N terminal + mRNA
    • 1lj2 – RvNSP34 C terminal + eukaryotic protein synthesis initiation factor peptide
    • 4r8r – DvNS5 residues 2491-2752 + adenosyl-Met
    • 4r8s – DvNS5 residues 2491-2752 + sinefungin
    • 6ux2 – ZvNS5 residues 2789-3419 + P113
    • 5rhg, 5rhh, 5rhi, 5rhj, 5rhk, 5rhl, 5rhm, 5rho, 5rhp, 5rhq, 5rhr, 5rhs, 5rht, 5rhu, 5rhv, 5rhw, 5rhx – ZvNS3 + inhibitor
    • 6jpw – ZvNS3 + NS2B + peptide
    • 6rwz, 6s0j – ZvNS3 + ADP
    • 6wcz – ZvNS5 + hSTAT2
    • 6i7p – ZvNS5 + SAH
    • 6jim – NS2 + RNA – Chicungunya virus
    • 6usm – NS1 + MBP – Human parvovirus
    • [6sx0]], 6zlc – IvNS1 RNA-binding domain + RNA
    • 6sx2 – IvNS1 RNA-binding domain (mutant) + RNA
    • 6e5u – IvNS1 + NXF1 + NXT1
    • 6mvo – HcvNS5B + inhibitor
    • 6qsn – NS5A + SAH – yellow fever virus
  • Nonstructural protein NS3 from SARS CoV-2; Domain 1564-1878 (papain-like protease), [[3241-3546 (3C-like proteinase) see Virus protease 3D structures
  • Other nonstructural protein from SARS CoV-2
    • 6zlw, 6zoj, 6zok, 6zol, 7k5i – Sv2NS1 in human 40S ribosome – Cryo EM
    • 6zmt, 6zn5 – Sv2NS1 in human pre-40S-like ribosome – Cryo EM
    • 6zp4, 6zon – Sv2NS1 in human 43S ribosome – Cryo EM
    • 6zm7, 6zme, 6zmi, 6zmo – Sv2NS1 in human 80S ribosome – Cryo EM
    • 7jqb, 7jqc – Sv2NS1 in rabbit 40S ribosome – Cryo EM
    • 7opl – Sv2NS1 13-127 + DNA polymerase + DNA primase – Cryo EM
    • 7k7p – Sv2NS1 1-180
    • 7msw, 7msx – Sv2NS2 – Cryo EM
    • 7exm – Sv2NS2 181-456
    • 2kys – Sv2NS7 3837-3919 – NMR
    • 7jtl – Sv2NS8 residues 18-121
    • 6w4b, 6wc1, 6wrb, 6wxd – Sv2NS9 residues 4141-4235
    • 6zct, 6zpe, 7nts – Sv2NS10 residues 4263-4384
    • 7orr, 7oru, 7orv, 7orw – Sv2NS10 residues 4263-4384 + imidazole derivative
    • 6z6i – Sv2NS10 residues 1024-1197 + ADP derivative
    • 5f22, 6m5i, 6wiq, 6wqd, 6wtc, 6xip, 6yhu, 7dcd, 7jlt – Sv2NS7 residues 3860-3930 + Sv2NS8 residues 4018-4134
    • 6m71, 7btf, 7bv1, 7bw4, 7d4f – Sv2NS7 residues 3860-3930 + Sv2NS8 residues 4018-4134 + Sv2NS12 residues 4393-5324 – Cryo EM
    • 6nur, 6nus – Sv2NS8 residues 4018-4134 + Sv2NS12 residues 4393-5324 – Cryo EM
    • 5rob, 6jyt, 6zsl, 7nio – SvNS13
    • 7diy – Sv2NS14 residues 5926-6214 + Sv2NS10 residues 4254-4392
    • 6vww, 6w01, 6xdh, 7kf4 – Sv2NS15 residues 6453-6798
    • 6w4h – Sv2NS16 residues 6799-7096 + Sv2NS10 residues 4254-4392
  • Other nonstructural protein from SARS CoV-2 complexes
    • 7ozu, 7ozv – Sv2NS7 residues 3860-3930 + Sv2NS8 residues 4018-4134 + RNA + replicase polyprotein – Cryo EM
    • 6xqb, 6yyt, 7bzf, 7c2k, 7cyq, [[[7dte]], [7krn]], 7kro, 7krp, 7l1f, 7oyg – Sv2NS7 residues 3860-3930 + Sv2NS8 residues 4018-4134 + Sv2NS12 residues 4393-5324 + RNA – Cryo EM
    • 7aap, 7b3b, 7b3c, 7bv2, 7ctt, 7dfg, 7dfh – Sv2NS7 residues 3860-3930 + Sv2NS8 residues 4018-4134 + Sv2NS12 residues 4393-5324 + RNA + drug – Cryo EM
    • 7b3d – Sv2NS7 residues 3860-3930 + Sv2NS8 residues 4018-4134 + Sv2NS12 residues 4393-5324 + RNA + AMP – Cryo EM
    • 7rdx, 7rdz, 7re3 – Sv2NS7 residues 3860-3930 + Sv2NS8 residues 4018-4134 + Sv2NS12 residues 4393-5324 + RNA + ADP + helicase – Cryo EM
    • 6xez, 7cxm, 7cxn, 7cyq – Sv2NS7 residues 3860-3930 + Sv2NS8 residues 4018-4134 + Sv2NS12 residues 4393-5324 + Sv2NS13 residues 5325-5925 + RNA – Cryo EM
    • 7n3k – Sv2NS9 residues 4141-4253 + drug
    • 7kri – Sv2NS9 residues 4141-4253 + pyrimidine derivative
    • 7mc5, 7mc6 – Sv2NS10 residues 4254-4392 + proofreading exoribonuclease
    • 7n0b, 7n0c, 7n0d – Sv2NS10 residues 4254-4392 + proofreading exoribonuclease + RNA – Cryo EM
    • 5rl6, 5rl7, 5rl8, 5rl9, 5rlc, 5rld, 5rle, 5rlf, 5rlg, 5rlh, 5rli, 5rlj, 5rlk, 5rll, 5rlm, 5rln, 5rlo, 5rlp, 5rlq, 5rlr, 5rls, 5rlt, 5rlu, 5rlv, 5rlw, 5rly, 5rlz, 5rm0, 5rm1, 5rm2, 5rm3, 5rm4, 5rm5, 5rm6, 5rm7, 5rm8, 5rm9, 5rma, 5rmb, 5rmc, 5rmd, 5rme, 5rmf, 5rmg, 5rmh, 5rmi, 5rmj, 5rmk 5rml, 5rmm, 7nng – SvNS13 + inhibitor
    • 7nn0 – SvNS13 + AMPPNP
    • [6wlc]], 6x4i, 7k1l – Sv2NS15 residues 6453-6798 + uridine derivative
    • 6wxc – Sv2NS15 residues 6453-6798 + drug
    • 6w61, 6w75, 6wvn, 6xkm, 7bq7, 7c2i, 7c2j, 7jpe, 7koa – Sv2NS16 residues 6799-7096 + Sv2NS10 residues 4254-4392 + SAM
    • 6wjt, 6wq3, 6wrz, 7jhe, 7lw3, 7lw4 – Sv2NS16 residues 6799-7096 + Sv2NS10 residues 4254-4392 + SAH
    • 7jib – Sv2NS16 residues 6799-7096 + Sv2NS10 residues 4254-4392 + SAH + SAM
    • 7jyy – Sv2NS16 residues 6799-7096 + Sv2NS10 residues 4254-4392 + SAM + RNA
    • 6wks – Sv2NS16 residues 6799-7096 + Sv2NS10 residues 4254-4392 + SAM + GpppA
    • 7jz0, 7l6r, 7l6t – Sv2NS16 residues 6799-7096 + Sv2NS10 residues 4254-4392 + SAH + RNA
    • 6wkq, 6yz1 – Sv2NS16 residues 6799-7096 + Sv2NS10 residues 4254-4392 + sinefungin
    • 6yyt – Sv2NS12 residues 4393-5324 + Sv2NS8 residues 3943-4140 + Sv2NS7 residues 3860-3942 + RNA

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Michal Harel, Joel L. Sussman

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