Transmembrane protease serine 2
From Proteopedia
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(New page: TMPRSS2 is a membrane protein belonging to the '''type II transmembrane serine protease (TTSP) family'''. It is functionally classified as a '''trypsin-like protease''' (TLP). <ref>DOI 10....) |
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TMPRSS2 is a membrane protein belonging to the '''type II transmembrane serine protease (TTSP) family'''. It is functionally classified as a '''trypsin-like protease''' (TLP). <ref>DOI 10.3389/fmolb.2021.666626</ref> Serine proteases are known to be involved in many physiological and pathological processes. | TMPRSS2 is a membrane protein belonging to the '''type II transmembrane serine protease (TTSP) family'''. It is functionally classified as a '''trypsin-like protease''' (TLP). <ref>DOI 10.3389/fmolb.2021.666626</ref> Serine proteases are known to be involved in many physiological and pathological processes. | ||
| - | == | + | == General function == |
| + | In terms of normal function, TMPRSS2 has | ||
| + | been associated with physiological and patholog�ical processes such as digestion, tissue remodel�ling, blood coagulation, fertility, inflammatory | ||
| + | responses, tumour cell invasion, apoptosis and | ||
| + | pain. <ref>DOI 10.1097/j.pain.0000000000000130</ref> | ||
| + | |||
<StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''> | <StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''> | ||
This is a default text for your page '''TMPRSS2'''. Click above on '''edit this page''' to modify. Be careful with the < and > signs. | This is a default text for your page '''TMPRSS2'''. Click above on '''edit this page''' to modify. Be careful with the < and > signs. | ||
Revision as of 15:43, 28 November 2021
TMPRSS2 is a membrane protein belonging to the type II transmembrane serine protease (TTSP) family. It is functionally classified as a trypsin-like protease (TLP). [1] Serine proteases are known to be involved in many physiological and pathological processes.
General function
In terms of normal function, TMPRSS2 has been associated with physiological and patholog�ical processes such as digestion, tissue remodel�ling, blood coagulation, fertility, inflammatory responses, tumour cell invasion, apoptosis and pain. [2]
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References
- ↑ Sgrignani J, Cavalli A. Computational Identification of a Putative Allosteric Binding Pocket in TMPRSS2. Front Mol Biosci. 2021 Apr 30;8:666626. doi: 10.3389/fmolb.2021.666626., eCollection 2021. PMID:33996911 doi:http://dx.doi.org/10.3389/fmolb.2021.666626
- ↑ Lam DK, Dang D, Flynn AN, Hardt M, Schmidt BL. TMPRSS2, a novel membrane-anchored mediator in cancer pain. Pain. 2015 May;156(5):923-930. doi: 10.1097/j.pain.0000000000000130. PMID:25734995 doi:http://dx.doi.org/10.1097/j.pain.0000000000000130
- ↑ Hanson, R. M., Prilusky, J., Renjian, Z., Nakane, T. and Sussman, J. L. (2013), JSmol and the Next-Generation Web-Based Representation of 3D Molecular Structure as Applied to Proteopedia. Isr. J. Chem., 53:207-216. doi:http://dx.doi.org/10.1002/ijch.201300024
- ↑ Herraez A. Biomolecules in the computer: Jmol to the rescue. Biochem Mol Biol Educ. 2006 Jul;34(4):255-61. doi: 10.1002/bmb.2006.494034042644. PMID:21638687 doi:10.1002/bmb.2006.494034042644
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