User:Maria Carolina Boer Copstein/Sandbox 1
From Proteopedia
(Difference between revisions)
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==Introduction == | ==Introduction == | ||
| - | VDAC1 is a protein present in the outer mitochondrial membrane(OMM).Mediate exchange of metabolites between mitochondria and cytoplasma. This protein is involved in several cellular processes.[[Image:MAM.jpg|300px|left|thumb| Your Caption Text]]VDAC1 has been shown to be a regulator of OMM permeability to Ca2+ | + | VDAC1 is a protein present in the outer mitochondrial membrane(OMM) e em outros compartimentos celulares como a membrana plásmatica.Mediate exchange of metabolites between mitochondria and cytoplasma. This protein is involved in several cellular processes.[[Image:MAM.jpg|300px|left|thumb| Your Caption Text]]VDAC1 has been shown to be a regulator of OMM permeability to Ca2+ |
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| + | == Relevance == | ||
| + | A VDAC1 por ser uma proteína da membrana mitocondrial está envolvida no metabolismo celular além de processos de apoptose dependentes da mitocôndria e regular a homeostase de cálcio e o estresse oxidativo. | ||
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| - | == | + | == Neurodegenerative disease == |
[[Image:MAMcopy.png|300px|right|thumb| Your Caption Text]] | [[Image:MAMcopy.png|300px|right|thumb| Your Caption Text]] | ||
| - | + | Diversos estudos já observaram a participação da VDAC1 nas disfunções mitocondriais observadas em várias doenças neurodegenerativas e constitui um ponto de acúmulo de agregados proteícos com a Tau,β amilóide,SOD1 que estão presentes nessas patologias.Devido o envolvimento da VDAC1 no metabolismo e em processos de apoptose essa proteína se torna um possível alvo terapêutico dessas doenças. | |
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== Structural highlights == | == Structural highlights == | ||
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Human VDAC1 (hVDAC1) adopts a β-barrel architecture composed of 19 <scene name='89/896608/Vdac1_helix/3'>β-strands</scene> with an <scene name='89/896608/Vdac1_helix/2'>α-helix</scene> located horizontally midway within the pore.<scene name='89/896608/Vdac1/3'>Ball and sticks structure</scene> | Human VDAC1 (hVDAC1) adopts a β-barrel architecture composed of 19 <scene name='89/896608/Vdac1_helix/3'>β-strands</scene> with an <scene name='89/896608/Vdac1_helix/2'>α-helix</scene> located horizontally midway within the pore.<scene name='89/896608/Vdac1/3'>Ball and sticks structure</scene> | ||
| - | == neurodegenerative diseases== | ||
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| - | This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes. | ||
</StructureSection> | </StructureSection> | ||
== References == | == References == | ||
| + | Magri Andrea ,Messina Angela, “Interactions of VDAC with Proteins Involved in Neurodegenerative Aggregation: An Opportunity for Advancement on Therapeutic Molecules”, Current Medicinal Chemistry 2017; 24(40) . https://doi.org/10.2174/0929867324666170601073920 | ||
<references/> | <references/> | ||
Revision as of 04:47, 29 November 2021
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References
Magri Andrea ,Messina Angela, “Interactions of VDAC with Proteins Involved in Neurodegenerative Aggregation: An Opportunity for Advancement on Therapeutic Molecules”, Current Medicinal Chemistry 2017; 24(40) . https://doi.org/10.2174/0929867324666170601073920
