Transmembrane protease serine 2
From Proteopedia
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== Structure == | == Structure == | ||
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| + | === Gene === | ||
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| + | The ''TMPRSS2'' gene resides on chromosome 21 at the band 21q22.3, and is split into 15 exons. It has an open reading frame of 492 amino acids. | ||
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| + | This gene is conserved in a wide variety of animals, such as chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, ''Caenorhabditis elegans'' and frog. | ||
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| + | === Protein === | ||
TPMRSS2 is defined by the presence of an N-terminal cytoplasmic domain, a transmembrane helical domain, and three extracellular domains: <ref>DOI 10.1136/jclinpath-2020-206987</ref> | TPMRSS2 is defined by the presence of an N-terminal cytoplasmic domain, a transmembrane helical domain, and three extracellular domains: <ref>DOI 10.1136/jclinpath-2020-206987</ref> | ||
Revision as of 11:39, 29 November 2021
TMPRSS2 is a membrane protein belonging to the type II transmembrane serine protease (TTSP) family. It is functionally classified as a trypsin-like protease (TLP). [1] Serine proteases are known to be involved in many physiological and pathological processes.
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References
- ↑ Sgrignani J, Cavalli A. Computational Identification of a Putative Allosteric Binding Pocket in TMPRSS2. Front Mol Biosci. 2021 Apr 30;8:666626. doi: 10.3389/fmolb.2021.666626., eCollection 2021. PMID:33996911 doi:http://dx.doi.org/10.3389/fmolb.2021.666626
- ↑ Evnin LB, Vasquez JR, Craik CS. Substrate specificity of trypsin investigated by using a genetic selection. Proc Natl Acad Sci U S A. 1990 Sep;87(17):6659-63. doi: 10.1073/pnas.87.17.6659. PMID:2204062 doi:http://dx.doi.org/10.1073/pnas.87.17.6659
- ↑ Singh N, Decroly E, Khatib AM, Villoutreix BO. Structure-based drug repositioning over the human TMPRSS2 protease domain: search for chemical probes able to repress SARS-CoV-2 Spike protein cleavages. Eur J Pharm Sci. 2020 Oct 1;153:105495. doi: 10.1016/j.ejps.2020.105495. Epub, 2020 Jul 28. PMID:32730844 doi:http://dx.doi.org/10.1016/j.ejps.2020.105495
- ↑ Lam DK, Dang D, Flynn AN, Hardt M, Schmidt BL. TMPRSS2, a novel membrane-anchored mediator in cancer pain. Pain. 2015 May;156(5):923-930. doi: 10.1097/j.pain.0000000000000130. PMID:25734995 doi:http://dx.doi.org/10.1097/j.pain.0000000000000130
- ↑ Thunders M, Delahunt B. Gene of the month: TMPRSS2 (transmembrane serine protease 2). J Clin Pathol. 2020 Dec;73(12):773-776. doi: 10.1136/jclinpath-2020-206987. Epub , 2020 Sep 1. PMID:32873700 doi:http://dx.doi.org/10.1136/jclinpath-2020-206987
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