2arw

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<StructureSection load='2arw' size='340' side='right'caption='[[2arw]], [[NMR_Ensembles_of_Models | 1 NMR models]]' scene=''>
<StructureSection load='2arw' size='340' side='right'caption='[[2arw]], [[NMR_Ensembles_of_Models | 1 NMR models]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2arw]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ARW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ARW FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2arw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ARW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ARW FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2arw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2arw OCA], [http://pdbe.org/2arw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2arw RCSB], [http://www.ebi.ac.uk/pdbsum/2arw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2arw ProSAT]</span></td></tr>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2arw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2arw OCA], [https://pdbe.org/2arw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2arw RCSB], [https://www.ebi.ac.uk/pdbsum/2arw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2arw ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/IL6RA_HUMAN IL6RA_HUMAN]] Part of the receptor for interleukin 6. Binds to IL6 with low affinity, but does not transduce a signal. Signal activation necessitate an association with IL6ST. Activation may lead to the regulation of the immune response, acute-phase reactions and hematopoiesis.<ref>PMID:11017875</ref> <ref>PMID:16270750</ref> Low concentration of a soluble form of IL6 receptor acts as an agonist of IL6 activity.<ref>PMID:11017875</ref> <ref>PMID:16270750</ref>
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[[https://www.uniprot.org/uniprot/IL6RA_HUMAN IL6RA_HUMAN]] Part of the receptor for interleukin 6. Binds to IL6 with low affinity, but does not transduce a signal. Signal activation necessitate an association with IL6ST. Activation may lead to the regulation of the immune response, acute-phase reactions and hematopoiesis.<ref>PMID:11017875</ref> <ref>PMID:16270750</ref> Low concentration of a soluble form of IL6 receptor acts as an agonist of IL6 activity.<ref>PMID:11017875</ref> <ref>PMID:16270750</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]

Revision as of 06:45, 1 December 2021

The solution structure of the membrane proximal cytokine receptor domain of the human interleukin-6 receptor

PDB ID 2arw

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