2cbo

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<StructureSection load='2cbo' size='340' side='right'caption='[[2cbo]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
<StructureSection load='2cbo' size='340' side='right'caption='[[2cbo]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2cbo]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/'streptomyces_carzinostaticus' 'streptomyces carzinostaticus']. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CBO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CBO FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2cbo]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/'streptomyces_carzinostaticus' 'streptomyces carzinostaticus']. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CBO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CBO FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TH2:TESTOSTERONE+HEMISUCCINATE'>TH2</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TH2:TESTOSTERONE+HEMISUCCINATE'>TH2</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1j5h|1j5h]], [[1j5i|1j5i]], [[1nco|1nco]], [[1noa|1noa]], [[1o5p|1o5p]], [[2cbm|2cbm]], [[2cbq|2cbq]], [[2cbt|2cbt]]</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1j5h|1j5h]], [[1j5i|1j5i]], [[1nco|1nco]], [[1noa|1noa]], [[1o5p|1o5p]], [[2cbm|2cbm]], [[2cbq|2cbq]], [[2cbt|2cbt]]</div></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cbo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cbo OCA], [http://pdbe.org/2cbo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2cbo RCSB], [http://www.ebi.ac.uk/pdbsum/2cbo PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2cbo ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cbo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cbo OCA], [https://pdbe.org/2cbo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cbo RCSB], [https://www.ebi.ac.uk/pdbsum/2cbo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cbo ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/NCZS_STRCZ NCZS_STRCZ]] NCS has antibiotic activity (for Gram-positive bacteria) and antitumor activity (for certain mouse tumors). NCS binds non-covalently to a chromophore which is the cytotoxic and mutagenic component of the antibiotic. The chromophore binds to DNA as a weak intercalator and causes single- and double-strand breaks.
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[[https://www.uniprot.org/uniprot/NCZS_STRCZ NCZS_STRCZ]] NCS has antibiotic activity (for Gram-positive bacteria) and antitumor activity (for certain mouse tumors). NCS binds non-covalently to a chromophore which is the cytotoxic and mutagenic component of the antibiotic. The chromophore binds to DNA as a weak intercalator and causes single- and double-strand breaks.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]

Revision as of 06:52, 1 December 2021

Crystal structure of the neocarzinostatin 3Tes24 mutant bound to testosterone hemisuccinate.

PDB ID 2cbo

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