User:Natalia de Araujo./Sandbox 1
From Proteopedia
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Through Co-IP [https://en.wikipedia.org/wiki/Immunoprecipitation#Protein_complex_immunoprecipitation_(Co-IP)]and MS[https://en.wikipedia.org/wiki/Mass_spectrometry] CEP170 was identified as a putative interactor with CHEK1, further confirmed with Co-IP in cells overexpressing CHEK1 <ref>DOI 10.1186/s12943-021-01380-0</ref> | Through Co-IP [https://en.wikipedia.org/wiki/Immunoprecipitation#Protein_complex_immunoprecipitation_(Co-IP)]and MS[https://en.wikipedia.org/wiki/Mass_spectrometry] CEP170 was identified as a putative interactor with CHEK1, further confirmed with Co-IP in cells overexpressing CHEK1 <ref>DOI 10.1186/s12943-021-01380-0</ref> | ||
| - | CHEK and circCHEK1_246aa (isoform from a cRNA) phosphorylate the Ser1260 residue of CEP170, which results in chromosomal instability seen in multiple myeloid cells. | + | CHEK and circCHEK1_246aa (isoform from a cRNA) phosphorylate the <scene name='89/897701/Ser_1260/1'>Ser1260</scene> residue of CEP170, which results in chromosomal instability seen in multiple myeloid cells. |
Revision as of 14:42, 3 December 2021
Centrosomal protein of 170kDa (CEP170)
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References
- ↑ Hanson, R. M., Prilusky, J., Renjian, Z., Nakane, T. and Sussman, J. L. (2013), JSmol and the Next-Generation Web-Based Representation of 3D Molecular Structure as Applied to Proteopedia. Isr. J. Chem., 53:207-216. doi:http://dx.doi.org/10.1002/ijch.201300024
- ↑ Herraez A. Biomolecules in the computer: Jmol to the rescue. Biochem Mol Biol Educ. 2006 Jul;34(4):255-61. doi: 10.1002/bmb.2006.494034042644. PMID:21638687 doi:10.1002/bmb.2006.494034042644
- ↑ Gu C, Wang W, Tang X, Xu T, Zhang Y, Guo M, Wei R, Wang Y, Jurczyszyn A, Janz S, Beksac M, Zhan F, Seckinger A, Hose D, Pan J, Yang Y. CHEK1 and circCHEK1_246aa evoke chromosomal instability and induce bone lesion formation in multiple myeloma. Mol Cancer. 2021 Jun 5;20(1):84. doi: 10.1186/s12943-021-01380-0. PMID:34090465 doi:http://dx.doi.org/10.1186/s12943-021-01380-0
Crystal structure of a centrosomal protein 170kDa, transcript variant beta (CEP170) from Homo sapiens at 2.15 A resolution (PSI Community Target, Sundstrom)
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