User:Natalia de Araujo./Sandbox 1

This is a default text for your page Natalia de Araujo./Sandbox 1. Click above on edit this page to modify. Be careful with the < and > signs.

You may include any references to papers as in: the use of JSmol in Proteopedia ^[1] or to the article describing Jmol ^[2] to the rescue.

The first structure loaded at the left side of the page correspond to 4jon, the Crystal structure of CEP170's transcript variant beta, from Homo sapiens.

4jon is a 5 chain structure obteined by X-ray Crystallography [1] and represents the first 126 residues of CEP170's N-termini region.

The second structure available for CEP170 is , a predicted 3D model obtteined by softwares.

Here we are going to focus on the Q5SW79 model due to its full sequence, allowing us to highlight residues and regions important for the understanding of CEP170's functions and interactions.

The Centrosomal Protein of 170 kDa (CEP170) is encoded by the gene CEP170, previously known as AKAA0470 [ref 1995].

The gene gives rise to 3 splice varients: CEP170α, CEP170β, and CEP170γ. The gene is expressed in a variety of tissues https://gtexportal.org/home/gene/CEP170

There are 2 3D models 4jon: Through X-ray Crystalografi Q5SW79: Predicted protein

Function

Microtubule organization Microtubule nucleation

Protein-Protein Interactions

• CHEK1 and circCHEK1_246aa

Through Co-IP [5]and MS[6] CEP170 was identified as a putative interactor with CHEK1, further confirmed with Co-IP in cells overexpressing CHEK1 ^[3] CHEK and circCHEK1_246aa (isoform from a cRNA) phosphorylate the residue of CEP170, which results in chromosomal instability seen in multiple myeloid cells.

Structural highlights

Disease

• • • https://proteopedia.org/wiki/index.php/Image:AF-Q5SW79-F1.pdb [imagem da proteina inteira]

This is a sample scene created with SAT to by Group, and another to make of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.