1fvg

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[[Image:1fvg.gif|left|200px]]
[[Image:1fvg.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1fvg |SIZE=350|CAPTION= <scene name='initialview01'>1fvg</scene>, resolution 1.6&Aring;
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The line below this paragraph, containing "STRUCTURE_1fvg", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=DTT:2,3-DIHYDROXY-1,4-DITHIOBUTANE'>DTT</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Peptide-methionine-(S)-S-oxide_reductase Peptide-methionine-(S)-S-oxide reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.8.4.11 1.8.4.11] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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|DOMAIN=
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{{STRUCTURE_1fvg| PDB=1fvg | SCENE= }}
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|RELATEDENTRY=[[1fva|1FVA]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1fvg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fvg OCA], [http://www.ebi.ac.uk/pdbsum/1fvg PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1fvg RCSB]</span>
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}}
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'''CRYSTAL STRUCTURE OF BOVINE PEPTIDE METHIONINE SULFOXIDE REDUCTASE'''
'''CRYSTAL STRUCTURE OF BOVINE PEPTIDE METHIONINE SULFOXIDE REDUCTASE'''
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Structure and mechanism of peptide methionine sulfoxide reductase, an "anti-oxidation" enzyme., Lowther WT, Brot N, Weissbach H, Matthews BW, Biochemistry. 2000 Nov 7;39(44):13307-12. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11063566 11063566]
Structure and mechanism of peptide methionine sulfoxide reductase, an "anti-oxidation" enzyme., Lowther WT, Brot N, Weissbach H, Matthews BW, Biochemistry. 2000 Nov 7;39(44):13307-12. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11063566 11063566]
[[Category: Bos taurus]]
[[Category: Bos taurus]]
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[[Category: Peptide-methionine-(S)-S-oxide reductase]]
 
[[Category: Single protein]]
[[Category: Single protein]]
[[Category: Brot, N.]]
[[Category: Brot, N.]]
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[[Category: Matthews, B W.]]
[[Category: Matthews, B W.]]
[[Category: Weissbach, H.]]
[[Category: Weissbach, H.]]
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[[Category: oxidoreductase]]
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[[Category: Oxidoreductase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 16:48:32 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 20:31:01 2008''
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Revision as of 13:48, 2 May 2008

Image:1fvg.gif

Template:STRUCTURE 1fvg

CRYSTAL STRUCTURE OF BOVINE PEPTIDE METHIONINE SULFOXIDE REDUCTASE


Overview

Peptide methionine sulfoxide reductase (MsrA) reverses oxidative damage to both free methionine and methionine within proteins. As such, it helps protect the host organism against stochastic damage that can contribute to cell death. The structure of bovine MsrA has been determined in two different modifications, both of which provide different insights into the biology of the protein. There are three cysteine residues located in the vicinity of the active site. Conformational changes in a glycine-rich C-terminal tail appear to allow all three thiols to come together and to participate in catalysis. The structures support a unique, thiol-disulfide exchange mechanism that relies upon an essential cysteine as a nucleophile and additional conserved residues that interact with the oxygen atom of the sulfoxide moiety.

About this Structure

1FVG is a Single protein structure of sequence from Bos taurus. Full crystallographic information is available from OCA.

Reference

Structure and mechanism of peptide methionine sulfoxide reductase, an "anti-oxidation" enzyme., Lowther WT, Brot N, Weissbach H, Matthews BW, Biochemistry. 2000 Nov 7;39(44):13307-12. PMID:11063566 Page seeded by OCA on Fri May 2 16:48:32 2008

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