6zuy
From Proteopedia
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==Human TFIIS N-terminal domain (TND)== | ==Human TFIIS N-terminal domain (TND)== | ||
| - | <StructureSection load='6zuy' size='340' side='right'caption='[[6zuy]]' scene=''> | + | <StructureSection load='6zuy' size='340' side='right'caption='[[6zuy]], [[NMR_Ensembles_of_Models | 40 NMR models]]' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full | + | <table><tr><td colspan='2'>[[6zuy]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ZUY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6ZUY FirstGlance]. <br> |
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6zuy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6zuy OCA], [https://pdbe.org/6zuy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6zuy RCSB], [https://www.ebi.ac.uk/pdbsum/6zuy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6zuy ProSAT]</span></td></tr> | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6zuy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6zuy OCA], [https://pdbe.org/6zuy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6zuy RCSB], [https://www.ebi.ac.uk/pdbsum/6zuy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6zuy ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Disease == | ||
| + | [[https://www.uniprot.org/uniprot/TCEA1_HUMAN TCEA1_HUMAN]] Note=A chromosomal aberration involving TCEA1 may be a cause of salivary gland pleiomorphic adenomas (PA) [181030]. Pleiomorphic adenomas are the most common benign epithelial tumors of the salivary gland. Translocation t(3;8)(p21;q12) with PLAG1. | ||
| + | == Function == | ||
| + | [[https://www.uniprot.org/uniprot/TCEA1_HUMAN TCEA1_HUMAN]] Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus. | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | [Figure: see text]. | ||
| + | |||
| + | A ubiquitous disordered protein interaction module orchestrates transcription elongation.,Cermakova K, Demeulemeester J, Lux V, Nedomova M, Goldman SR, Smith EA, Srb P, Hexnerova R, Fabry M, Madlikova M, Horejsi M, De Rijck J, Debyser Z, Adelman K, Hodges HC, Veverka V Science. 2021 Nov 26;374(6571):1113-1121. doi: 10.1126/science.abe2913. Epub 2021, Nov 25. PMID:34822292<ref>PMID:34822292</ref> | ||
| + | |||
| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 6zuy" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Veverka V]] | + | [[Category: Veverka, V]] |
| + | [[Category: Elongation factor]] | ||
| + | [[Category: Transcription]] | ||
Revision as of 10:01, 8 December 2021
Human TFIIS N-terminal domain (TND)
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