6zv4
From Proteopedia
(Difference between revisions)
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==Human TFIIS N-terminal domain in complex with IWS1== | ==Human TFIIS N-terminal domain in complex with IWS1== | ||
| - | <StructureSection load='6zv4' size='340' side='right'caption='[[6zv4]]' scene=''> | + | <StructureSection load='6zv4' size='340' side='right'caption='[[6zv4]], [[NMR_Ensembles_of_Models | 40 NMR models]]' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full | + | <table><tr><td colspan='2'>[[6zv4]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ZV4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6ZV4 FirstGlance]. <br> |
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6zv4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6zv4 OCA], [https://pdbe.org/6zv4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6zv4 RCSB], [https://www.ebi.ac.uk/pdbsum/6zv4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6zv4 ProSAT]</span></td></tr> | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6zv4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6zv4 OCA], [https://pdbe.org/6zv4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6zv4 RCSB], [https://www.ebi.ac.uk/pdbsum/6zv4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6zv4 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Disease == | ||
| + | [[https://www.uniprot.org/uniprot/TCEA1_HUMAN TCEA1_HUMAN]] Note=A chromosomal aberration involving TCEA1 may be a cause of salivary gland pleiomorphic adenomas (PA) [181030]. Pleiomorphic adenomas are the most common benign epithelial tumors of the salivary gland. Translocation t(3;8)(p21;q12) with PLAG1. | ||
| + | == Function == | ||
| + | [[https://www.uniprot.org/uniprot/TCEA1_HUMAN TCEA1_HUMAN]] Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus. | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | [Figure: see text]. | ||
| + | |||
| + | A ubiquitous disordered protein interaction module orchestrates transcription elongation.,Cermakova K, Demeulemeester J, Lux V, Nedomova M, Goldman SR, Smith EA, Srb P, Hexnerova R, Fabry M, Madlikova M, Horejsi M, De Rijck J, Debyser Z, Adelman K, Hodges HC, Veverka V Science. 2021 Nov 26;374(6571):1113-1121. doi: 10.1126/science.abe2913. Epub 2021, Nov 25. PMID:34822292<ref>PMID:34822292</ref> | ||
| + | |||
| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 6zv4" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Veverka V]] | + | [[Category: Veverka, V]] |
| + | [[Category: Transcription]] | ||
| + | [[Category: Transcription elongation]] | ||
Revision as of 10:01, 8 December 2021
Human TFIIS N-terminal domain in complex with IWS1
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