2cy9
From Proteopedia
(Difference between revisions)
| Line 3: | Line 3: | ||
<StructureSection load='2cy9' size='340' side='right'caption='[[2cy9]], [[Resolution|resolution]] 2.72Å' scene=''> | <StructureSection load='2cy9' size='340' side='right'caption='[[2cy9]], [[Resolution|resolution]] 2.72Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2cy9]] is a 2 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[2cy9]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CY9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CY9 FirstGlance]. <br> |
</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> | </td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> | ||
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cy9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cy9 OCA], [https://pdbe.org/2cy9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cy9 RCSB], [https://www.ebi.ac.uk/pdbsum/2cy9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cy9 ProSAT], [https://www.topsan.org/Proteins/RSGI/2cy9 TOPSAN]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/ACO13_MOUSE ACO13_MOUSE]] Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Has acyl-CoA thioesterase activity towards medium (C12) and long-chain (C18) fatty acyl-CoA substrates. Can also hydrolyze 3-hydroxyphenylacetyl-CoA (in vitro). May play a role in controlling adaptive thermogenesis.<ref>PMID:19405909</ref> <ref>PMID:24072708</ref> |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Revision as of 10:23, 8 December 2021
Crystal structure of thioesterase superfamily member2 from Mus musculus
| |||||||||||
