2d68

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<StructureSection load='2d68' size='340' side='right'caption='[[2d68]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
<StructureSection load='2d68' size='340' side='right'caption='[[2d68]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2d68]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2D68 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2D68 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2d68]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2D68 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2D68 FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2d68 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2d68 OCA], [http://pdbe.org/2d68 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2d68 RCSB], [http://www.ebi.ac.uk/pdbsum/2d68 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2d68 ProSAT]</span></td></tr>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2d68 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2d68 OCA], [https://pdbe.org/2d68 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2d68 RCSB], [https://www.ebi.ac.uk/pdbsum/2d68 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2d68 ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
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[[http://www.uniprot.org/uniprot/FR1OP_HUMAN FR1OP_HUMAN]] Note=A chromosomal aberration involving FGFR1OP may be a cause of stem cell myeloproliferative disorder (MPD). Translocation t(6;8)(q27;p11) with FGFR1. MPD is characterized by myeloid hyperplasia, eosinophilia and T-cell or B-cell lymphoblastic lymphoma. In general it progresses to acute myeloid leukemia. The fusion proteins FGFR1OP-FGFR1 or FGFR1-FGFR1OP may exhibit constitutive kinase activity and be responsible for the transforming activity.
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[[https://www.uniprot.org/uniprot/FR1OP_HUMAN FR1OP_HUMAN]] Note=A chromosomal aberration involving FGFR1OP may be a cause of stem cell myeloproliferative disorder (MPD). Translocation t(6;8)(q27;p11) with FGFR1. MPD is characterized by myeloid hyperplasia, eosinophilia and T-cell or B-cell lymphoblastic lymphoma. In general it progresses to acute myeloid leukemia. The fusion proteins FGFR1OP-FGFR1 or FGFR1-FGFR1OP may exhibit constitutive kinase activity and be responsible for the transforming activity.
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/FR1OP_HUMAN FR1OP_HUMAN]] Required for anchoring microtubules to the centrosomes.<ref>PMID:16314388</ref>
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[[https://www.uniprot.org/uniprot/FR1OP_HUMAN FR1OP_HUMAN]] Required for anchoring microtubules to the centrosomes.<ref>PMID:16314388</ref>
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<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==

Revision as of 10:28, 8 December 2021

Structure of the N-terminal domain of FOP (FGFR1OP) protein

PDB ID 2d68

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