2dha
From Proteopedia
(Difference between revisions)
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<StructureSection load='2dha' size='340' side='right'caption='[[2dha]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | <StructureSection load='2dha' size='340' side='right'caption='[[2dha]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2dha]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[2dha]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DHA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DHA FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2dha FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dha OCA], [https://pdbe.org/2dha PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2dha RCSB], [https://www.ebi.ac.uk/pdbsum/2dha PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2dha ProSAT], [https://www.topsan.org/Proteins/RSGI/2dha TOPSAN]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/ESRP1_HUMAN ESRP1_HUMAN]] mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2. Also regulates the splicing of CD44, CTNND1, ENAH, 3 transcripts that undergo changes in splicing during the epithelial-to-mesenchymal transition (EMT). Acts by directly binding specific sequences in mRNAs. Binds the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of FGFR2. |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Revision as of 10:31, 8 December 2021
Solution structure of the second RNA recognition motif in Hypothetical protein FLJ201171
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