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2yuk

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==Solution structure of the HMG box of human Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog==
==Solution structure of the HMG box of human Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog==
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<StructureSection load='2yuk' size='340' side='right' caption='[[2yuk]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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<StructureSection load='2yuk' size='340' side='right'caption='[[2yuk]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2yuk]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YUK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2YUK FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2yuk]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YUK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YUK FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MLL3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MLL3 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Histone-lysine_N-methyltransferase Histone-lysine N-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.43 2.1.1.43] </span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Histone-lysine_N-methyltransferase Histone-lysine N-methyltransferase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.43 2.1.1.43] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2yuk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yuk OCA], [http://pdbe.org/2yuk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2yuk RCSB], [http://www.ebi.ac.uk/pdbsum/2yuk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2yuk ProSAT], [http://www.topsan.org/Proteins/RSGI/2yuk TOPSAN]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2yuk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yuk OCA], [https://pdbe.org/2yuk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2yuk RCSB], [https://www.ebi.ac.uk/pdbsum/2yuk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2yuk ProSAT], [https://www.topsan.org/Proteins/RSGI/2yuk TOPSAN]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/MLL3_HUMAN MLL3_HUMAN]] Histone methyltransferase. Methylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Central component of the MLL2/3 complex, a coactivator complex of nuclear receptors, involved in transcriptional coactivation. MLL3 may be a catalytic subunit of this complex. May be involved in leukemogenesis and developmental disorder.<ref>PMID:17500065</ref>
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[[https://www.uniprot.org/uniprot/MLL3_HUMAN MLL3_HUMAN]] Histone methyltransferase. Methylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Central component of the MLL2/3 complex, a coactivator complex of nuclear receptors, involved in transcriptional coactivation. MLL3 may be a catalytic subunit of this complex. May be involved in leukemogenesis and developmental disorder.<ref>PMID:17500065</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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[[Category: Histone-lysine N-methyltransferase]]
[[Category: Histone-lysine N-methyltransferase]]
[[Category: Human]]
[[Category: Human]]
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[[Category: Large Structures]]
[[Category: Abe, H]]
[[Category: Abe, H]]
[[Category: Harada, T]]
[[Category: Harada, T]]

Revision as of 10:39, 8 December 2021

Solution structure of the HMG box of human Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog

PDB ID 2yuk

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