2yuk
From Proteopedia
(Difference between revisions)
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==Solution structure of the HMG box of human Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog== | ==Solution structure of the HMG box of human Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog== | ||
| - | <StructureSection load='2yuk' size='340' side='right' caption='[[2yuk]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | + | <StructureSection load='2yuk' size='340' side='right'caption='[[2yuk]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2yuk]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[2yuk]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YUK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YUK FirstGlance]. <br> |
| - | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MLL3 ([ | + | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MLL3 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> |
| - | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Histone-lysine_N-methyltransferase Histone-lysine N-methyltransferase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.43 2.1.1.43] </span></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2yuk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yuk OCA], [https://pdbe.org/2yuk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2yuk RCSB], [https://www.ebi.ac.uk/pdbsum/2yuk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2yuk ProSAT], [https://www.topsan.org/Proteins/RSGI/2yuk TOPSAN]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/MLL3_HUMAN MLL3_HUMAN]] Histone methyltransferase. Methylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Central component of the MLL2/3 complex, a coactivator complex of nuclear receptors, involved in transcriptional coactivation. MLL3 may be a catalytic subunit of this complex. May be involved in leukemogenesis and developmental disorder.<ref>PMID:17500065</ref> |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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[[Category: Histone-lysine N-methyltransferase]] | [[Category: Histone-lysine N-methyltransferase]] | ||
[[Category: Human]] | [[Category: Human]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Abe, H]] | [[Category: Abe, H]] | ||
[[Category: Harada, T]] | [[Category: Harada, T]] | ||
Revision as of 10:39, 8 December 2021
Solution structure of the HMG box of human Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog
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Categories: Histone-lysine N-methyltransferase | Human | Large Structures | Abe, H | Harada, T | Kigawa, T | Koshiba, S | Miyamoto, K | Structural genomic | Tochio, N | Watanabe, S | Yokoyama, S | H3 lysine-4 specific mll3 | Histone-lysine n-methyltransferase | Homologous to alr protein | National project on protein structural and functional analyse | Nppsfa | Rsgi | Transferase
