2zec

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==Potent, Nonpeptide Inhibitors of Human Mast Cell Tryptase==
==Potent, Nonpeptide Inhibitors of Human Mast Cell Tryptase==
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<StructureSection load='2zec' size='340' side='right' caption='[[2zec]], [[Resolution|resolution]] 2.06&Aring;' scene=''>
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<StructureSection load='2zec' size='340' side='right'caption='[[2zec]], [[Resolution|resolution]] 2.06&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2zec]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZEC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ZEC FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2zec]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZEC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ZEC FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=11N:1-[1-(3-PHENYLACRYLOYL)SPIRO[1-BENZOFURAN-3,4-PIPERIDIN]-5-YL]METHANAMINE'>11N</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=11N:1-[1-(3-PHENYLACRYLOYL)SPIRO[1-BENZOFURAN-3,4-PIPERIDIN]-5-YL]METHANAMINE'>11N</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2zeb|2zeb]]</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2zeb|2zeb]]</div></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">TPSB2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">TPSB2 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2zec FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zec OCA], [http://pdbe.org/2zec PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2zec RCSB], [http://www.ebi.ac.uk/pdbsum/2zec PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2zec ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2zec FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zec OCA], [https://pdbe.org/2zec PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2zec RCSB], [https://www.ebi.ac.uk/pdbsum/2zec PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2zec ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/TRYB1_HUMAN TRYB1_HUMAN]] Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type (By similarity).
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[[https://www.uniprot.org/uniprot/TRYB1_HUMAN TRYB1_HUMAN]] Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type (By similarity).
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ze/2zec_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ze/2zec_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
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</div>
</div>
<div class="pdbe-citations 2zec" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 2zec" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Tryptase|Tryptase]]
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Human]]
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[[Category: Large Structures]]
[[Category: Lewandowski, F]]
[[Category: Lewandowski, F]]
[[Category: Milligan, C]]
[[Category: Milligan, C]]

Revision as of 10:51, 8 December 2021

Potent, Nonpeptide Inhibitors of Human Mast Cell Tryptase

PDB ID 2zec

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