User:Victória Marcelle do Nascimento/caixa de areia 6117

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<Structure load='Insert PDB code or filename here' size='350' frame='true' align='right' caption='Insert caption here' scene='Insert optional scene name here' />
<Structure load='Insert PDB code or filename here' size='350' frame='true' align='right' caption='Insert caption here' scene='Insert optional scene name here' />
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Endostatin is a polypeptide of 184 amino acids, corresponding to the globular domain found at the C-terminal of type XVIII collagen, and it is the most studied of the endogenous angiogenesis inhibitors.
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A endostatina é um polipeptídeo de 184 aminoácidos, correspondente ao domínio globular encontrado no terminal C do colágeno tipo XVIII, uma proteína globular contendo duas ligações de dissulfeto: Cys162-302 e Cys264-294. Além disso, ela possui um domínio de ligação de zinco no n-terminal da proteína e tem uma alta afinidade com heparina. A endostatina foi originalmente isolada como inibidora da angiogênese e foi proposta como agente terapêutico anti tumoral, sendo a mais estudada dos inibidores da angiogênese endógena.
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Endostatin, a putative antiangiogenic factor, is a 20-kDa proteolytic fragment of collagen XVIII.29 Recombinant endostatin and its related fragments have been shown to inhibit bFGF-induced corneal NV in vivo and bFGF- and VEGF-induced vascular endothelial cell migration and proliferation in vitro.30 Specifically, endostatin implanted in the cornea demonstrated an inhibition of the bFGF-induced NV. Collagen XVIII is a nonfibrillar collagen localized mainly to the corneal vascular and epithelial basement membrane. Cleavage of collagen XVIII by proteases (including MMPs, cathepsin L, and elastase) generates endostatin-like fragments that may display antiangiogenic properties. Local production of endostatin may occur during corneal wound healing, as both the cleaving enzymes (MMPs) and the substrate (collagen XVIII) are present in the basement membrane area to prevent corneal NV. Endostatin has been approved by the US Food and Drug Administration (FDA) for the treatment of NV-related cancer; thus, it may be an additional drug that can be added to anti-VEGF therapy to treat corneal NV- and lymphangiogenesis-related disorders.
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Doença de Hialoma: A Endostatina mostrou-se ser um produto de decote proteolítico de colágeno 18. Embora o potencial terapêutico da endostatina ainda não tenha sido realizado, o fragmento de colágeno mutante 18, no qual nenhuma produção de endostatina é possível, tem um efeito na regressão hialoide.
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Esta interessante observação do grupo Olsen indicou que o colágeno 18, e talvez a endostatina, promovem a regressão do vaso e é consistente com a atividade anti-angiogênica originalmente identificada da endostatina.
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This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.
This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.

Revision as of 22:32, 8 December 2021

Estrutura Endostatina

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References

  1. ↑ Hanson, R. M., Prilusky, J., Renjian, Z., Nakane, T. and Sussman, J. L. (2013), JSmol and the Next-Generation Web-Based Representation of 3D Molecular Structure as Applied to Proteopedia. Isr. J. Chem., 53:207-216. doi:http://dx.doi.org/10.1002/ijch.201300024
  2. ↑ Herraez A. Biomolecules in the computer: Jmol to the rescue. Biochem Mol Biol Educ. 2006 Jul;34(4):255-61. doi: 10.1002/bmb.2006.494034042644. PMID:21638687 doi:10.1002/bmb.2006.494034042644

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Victória Marcelle do Nascimento

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