Talk:SARS-CoV-2 Papain-Like protease (PLpro)
From Proteopedia
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| + | == Introduction == | ||
| + | Papain-like protease (PLpro) from SARS-CoV-2 is a 315 amino acids long cysteine protease is found in the large multi-domain membrane-bound non-structural protein 3 (nsp3)(1945 residues) between the SARS domain (SUD/HVR) and a nucleic acid-binding domain (NAD) (Frick et al, 2020, OSIPIUK et al., 2021). It has a high percentage of cysteine residues (3.5%) (OSIPIUK et al., 2021). | ||
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| + | == SARS-CoV-2 polyprotein == | ||
| + | The first SARS-CoV-2 open reading frame (ORF) codes for one large polyprotein, 1ab (7096 aminoacids) or 1a (4405 amino acids) built by fifteen non-coding proteins including the two proteases responsible to cleave the polyprotein: Main protease (Mpro or 3Cl-pro) and Papain-Like protease (OSIPIUK et al., 2021). | ||
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<scene name='89/898905/Helix_and_sheet/2'>PLpro</scene> | <scene name='89/898905/Helix_and_sheet/2'>PLpro</scene> | ||
<scene name='89/898905/Cys_residues/2'>Cysteine Residue on PLpro</scene> | <scene name='89/898905/Cys_residues/2'>Cysteine Residue on PLpro</scene> | ||
Revision as of 21:52, 12 December 2021
Introduction
Papain-like protease (PLpro) from SARS-CoV-2 is a 315 amino acids long cysteine protease is found in the large multi-domain membrane-bound non-structural protein 3 (nsp3)(1945 residues) between the SARS domain (SUD/HVR) and a nucleic acid-binding domain (NAD) (Frick et al, 2020, OSIPIUK et al., 2021). It has a high percentage of cysteine residues (3.5%) (OSIPIUK et al., 2021).
SARS-CoV-2 polyprotein
The first SARS-CoV-2 open reading frame (ORF) codes for one large polyprotein, 1ab (7096 aminoacids) or 1a (4405 amino acids) built by fifteen non-coding proteins including the two proteases responsible to cleave the polyprotein: Main protease (Mpro or 3Cl-pro) and Papain-Like protease (OSIPIUK et al., 2021).
