Phospholipase D

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[[4q6x]] – PLD – cave spider<br />
[[4q6x]] – PLD – cave spider<br />
[[2ze4]], [[1v0r]], [[1v0s]], [[1f0i]] – SaPLD – ''Streptomyces antibioticus''<br />
[[2ze4]], [[1v0r]], [[1v0s]], [[1f0i]] – SaPLD – ''Streptomyces antibioticus''<br />
 +
[[7jrb]] – SaPLD (mutant) <br />
[[1v0v]], [[1v0w]] – SaPLD + phosphite<br />
[[1v0v]], [[1v0w]] – SaPLD + phosphite<br />
[[1v0y]] – SaPLD + phosphatidylcholine derivative<br />
[[1v0y]] – SaPLD + phosphatidylcholine derivative<br />
[[2ze9]] – SaPLD (mutant) + phosphatidylcholine<br />
[[2ze9]] – SaPLD (mutant) + phosphatidylcholine<br />
[[1v0t]], [[1v0u]] – SaPLD + glycerophosphate<br />
[[1v0t]], [[1v0u]] – SaPLD + glycerophosphate<br />
 +
[[7jrc]] – SaPLD (mutant) + phosphate<br />
 +
[[7js5]], [[7js7]] – SaPLD (mutant) + inositol phosphate<br />
 +
[[7jru]], [[7jrv]], [[7jrw]] – SaPLD (mutant) + phosphatidic acid<br />
[[6kz9]] – AtPLD a 1 – ''Arabidopsis thaliana''<br />
[[6kz9]] – AtPLD a 1 – ''Arabidopsis thaliana''<br />
[[6kz8]] – AtPLD a 1 + phosphatidic acid <br />
[[6kz8]] – AtPLD a 1 + phosphatidic acid <br />

Revision as of 09:53, 14 December 2021

Phospholipase D complex with substrate dibutyrylphosphatidylcholine (PDB code 1v0y)

Drag the structure with the mouse to rotate

3D structures of phospholipase D

Updated on 14-December-2021

6u8z – hPLD1 catalytic domain 330-500, 643-1074 – human
6ohr – hPLD1 catalytic domain + inhibitor
6ohm, 6oho – hPLD2 catalytic domain 294-933
6ohq, 6ohs, 6ohp – hPLD2 catalytic domain + inhibitor
4rw3 – bsPLD – brown spider
4rw5 – bsPLD (mutant)
3rlg, 3rlh – PLD (mutant) – Loxosceles intemedia
4q6x – PLD – cave spider
2ze4, 1v0r, 1v0s, 1f0i – SaPLD – Streptomyces antibioticus
7jrb – SaPLD (mutant)
1v0v, 1v0w – SaPLD + phosphite
1v0y – SaPLD + phosphatidylcholine derivative
2ze9 – SaPLD (mutant) + phosphatidylcholine
1v0t, 1v0u – SaPLD + glycerophosphate
7jrc – SaPLD (mutant) + phosphate
7js5, 7js7 – SaPLD (mutant) + inositol phosphate
7jru, 7jrv, 7jrw – SaPLD (mutant) + phosphatidic acid
6kz9 – AtPLD a 1 – Arabidopsis thaliana
6kz8 – AtPLD a 1 + phosphatidic acid

References

  1. ↑ McDermott M, Wakelam MJ, Morris AJ. Phospholipase D. Biochem Cell Biol. 2004 Feb;82(1):225-53. PMID:15052340 doi:http://dx.doi.org/10.1139/o03-079
  2. ↑ Oliveira TG, Di Paolo G. Phospholipase D in brain function and Alzheimer's disease. Biochim Biophys Acta. 2010 Aug;1801(8):799-805. doi:, 10.1016/j.bbalip.2010.04.004. Epub 2010 Apr 23. PMID:20399893 doi:http://dx.doi.org/10.1016/j.bbalip.2010.04.004
  3. ↑ Leiros I, McSweeney S, Hough E. The reaction mechanism of phospholipase D from Streptomyces sp. strain PMF. Snapshots along the reaction pathway reveal a pentacoordinate reaction intermediate and an unexpected final product. J Mol Biol. 2004 Jun 11;339(4):805-20. PMID:15165852 doi:http://dx.doi.org/10.1016/j.jmb.2004.04.003

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