2ziv
From Proteopedia
(Difference between revisions)
Line 1: | Line 1: | ||
==Crystal structure of the Mus81-Eme1 complex== | ==Crystal structure of the Mus81-Eme1 complex== | ||
- | <StructureSection load='2ziv' size='340' side='right' caption='[[2ziv]], [[Resolution|resolution]] 2.70Å' scene=''> | + | <StructureSection load='2ziv' size='340' side='right'caption='[[2ziv]], [[Resolution|resolution]] 2.70Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
- | <table><tr><td colspan='2'>[[2ziv]] is a 2 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[2ziv]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Brachidanio_rerio Brachidanio rerio] and [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZIV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ZIV FirstGlance]. <br> |
- | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2ziu|2ziu]], [[2ziw|2ziw]], [[2zix|2zix]]</td></tr> | + | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2ziu|2ziu]], [[2ziw|2ziw]], [[2zix|2zix]]</div></td></tr> |
- | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">mus81 ([ | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">mus81 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7955 Brachidanio rerio]), EME1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> |
- | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ziv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ziv OCA], [https://pdbe.org/2ziv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ziv RCSB], [https://www.ebi.ac.uk/pdbsum/2ziv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ziv ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
- | [[ | + | [[https://www.uniprot.org/uniprot/EME1_HUMAN EME1_HUMAN]] Interacts with MUS81 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication forks.<ref>PMID:12686547</ref> <ref>PMID:12721304</ref> <ref>PMID:14617801</ref> <ref>PMID:17289582</ref> |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
- | <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zi/2ziv_consurf.spt"</scriptWhenChecked> | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zi/2ziv_consurf.spt"</scriptWhenChecked> |
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
Line 31: | Line 31: | ||
==See Also== | ==See Also== | ||
- | *[[Endonuclease|Endonuclease]] | + | *[[Endonuclease 3D structures|Endonuclease 3D structures]] |
== References == | == References == | ||
<references/> | <references/> | ||
Line 38: | Line 38: | ||
[[Category: Brachidanio rerio]] | [[Category: Brachidanio rerio]] | ||
[[Category: Human]] | [[Category: Human]] | ||
+ | [[Category: Large Structures]] | ||
[[Category: Chang, J H]] | [[Category: Chang, J H]] | ||
[[Category: Cho, Y]] | [[Category: Cho, Y]] |
Revision as of 17:31, 15 December 2021
Crystal structure of the Mus81-Eme1 complex
|
Categories: Brachidanio rerio | Human | Large Structures | Chang, J H | Cho, Y | Choi, J M | Kim, J J | Lee, J H | Alternative splicing | Dna damage | Dna recombination | Dna repair | Endonuclease | Helix-hairpin-helix | Hydrolase | Magnesium | Metal-binding | Nuclease | Nucleus | Phosphoprotein | Polymorphism