2zof
From Proteopedia
(Difference between revisions)
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==Crystal structure of mouse carnosinase CN2 complexed with MN and bestatin== | ==Crystal structure of mouse carnosinase CN2 complexed with MN and bestatin== | ||
- | <StructureSection load='2zof' size='340' side='right' caption='[[2zof]], [[Resolution|resolution]] 2.30Å' scene=''> | + | <StructureSection load='2zof' size='340' side='right'caption='[[2zof]], [[Resolution|resolution]] 2.30Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
- | <table><tr><td colspan='2'>[[2zof]] is a 2 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[2zof]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZOF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ZOF FirstGlance]. <br> |
- | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BES:2-(3-AMINO-2-HYDROXY-4-PHENYL-BUTYRYLAMINO)-4-METHYL-PENTANOIC+ACID'>BES</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BES:2-(3-AMINO-2-HYDROXY-4-PHENYL-BUTYRYLAMINO)-4-METHYL-PENTANOIC+ACID'>BES</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr> |
- | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2zog|2zog]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2zog|2zog]]</div></td></tr> |
- | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Cndp2, Cn2 ([ | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Cndp2, Cn2 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr> |
- | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Cytosol_nonspecific_dipeptidase Cytosol nonspecific dipeptidase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.13.18 3.4.13.18] </span></td></tr> |
- | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2zof FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zof OCA], [https://pdbe.org/2zof PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2zof RCSB], [https://www.ebi.ac.uk/pdbsum/2zof PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2zof ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
- | [[ | + | [[https://www.uniprot.org/uniprot/CNDP2_MOUSE CNDP2_MOUSE]] Hydrolyzes a variety of dipeptides including L-carnosine. Has a strong preference for Cys-Gly (By similarity). |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Cytosol nonspecific dipeptidase]] | [[Category: Cytosol nonspecific dipeptidase]] | ||
+ | [[Category: Large Structures]] | ||
[[Category: Lk3 transgenic mice]] | [[Category: Lk3 transgenic mice]] | ||
[[Category: Kusunoki, M]] | [[Category: Kusunoki, M]] |
Revision as of 17:34, 15 December 2021
Crystal structure of mouse carnosinase CN2 complexed with MN and bestatin
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Categories: Cytosol nonspecific dipeptidase | Large Structures | Lk3 transgenic mice | Kusunoki, M | Okumura, N | Unno, H | Yamashita, T | Bestatin | Carboxypeptidase | Carnosinase | Cn2 | Cndp dipeptidase 2 | Cndp2 | Hydrolase | L-carnosine | Metal-binding | Metallopeptidase | Metalloprotease | Mn | Protease | Protein-inhibitor complex | Zinc