Journal:Acta Cryst F:S2053230X21013455
From Proteopedia
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*<scene name='89/899476/Cv/2'>Monomer of apo BpBADH</scene>, colored in rainbow from blue (N-terminus) to red (C-terminus); [[6wsa]]. | *<scene name='89/899476/Cv/2'>Monomer of apo BpBADH</scene>, colored in rainbow from blue (N-terminus) to red (C-terminus); [[6wsa]]. | ||
*<scene name='89/899476/Cv/3'>Dimer of BpBADH with NAD</scene>, monomers are shown as green and cyan ribbons, with NAD shown as ball-and-sticks; [[6wsb]]. | *<scene name='89/899476/Cv/3'>Dimer of BpBADH with NAD</scene>, monomers are shown as green and cyan ribbons, with NAD shown as ball-and-sticks; [[6wsb]]. | ||
| - | The structures are similar to those of BADH from ''Pseudomonas aeruginosa'' (''Pa''BADH). ''Pa''BADH is inhibited by the drug disulfiram which is an approved drug. Our preliminary analysis could facilitate drug repurposing studies for melioidosis. This project is an educational collaboration between the SSGCID and Hampton University. The SSGCID consortium is directed by Dr. Peter Myler (principal investigator) and comprises many different scientists working at multiple centers towards determining the three-dimensional structures of proteins from biodefense organisms and emerging infectious diseases. Dylan K. Beard was part of a pilot Hampton University Chemistry Education and Mentorship Course-based undergraduate research (HU-ChEM CURES) funded by the NIGMS. | + | The structures are similar to those of BADH from ''Pseudomonas aeruginosa'' (''Pa''BADH): |
| + | *<scene name='89/899476/Cv/5'>Co-factor binding domain of BpBADH</scene> ([[6wsb]]). | ||
| + | ''Pa''BADH is inhibited by the drug disulfiram which is an approved drug. Our preliminary analysis could facilitate drug repurposing studies for melioidosis. This project is an educational collaboration between the SSGCID and Hampton University. The SSGCID consortium is directed by Dr. Peter Myler (principal investigator) and comprises many different scientists working at multiple centers towards determining the three-dimensional structures of proteins from biodefense organisms and emerging infectious diseases. Dylan K. Beard was part of a pilot Hampton University Chemistry Education and Mentorship Course-based undergraduate research (HU-ChEM CURES) funded by the NIGMS. | ||
<b>References</b><br> | <b>References</b><br> | ||
Revision as of 12:31, 20 December 2021
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This page complements a publication in scientific journals and is one of the Proteopedia's Interactive 3D Complement pages. For aditional details please see I3DC.
