1d2q
From Proteopedia
OCA (Talk | contribs)
(New page: 200px<br /> <applet load="1d2q" size="450" color="white" frame="true" align="right" spinBox="true" caption="1d2q, resolution 2.8Å" /> '''CRYSTAL STRUCTURE OF...)
Next diff →
Revision as of 14:21, 12 November 2007
|
CRYSTAL STRUCTURE OF HUMAN TRAIL
Contents |
Overview
TRAIL is a newly identified cytokine belonging to the large tumor necrosis, factor (TNF) family. TRAIL is a novel molecule inducing apoptosis in a, wide variety of tumor cells but not in normal cells. To help in, elucidating its biological roles and designing mutants with improved, therapeutic potential, we have determined the crystal structure of human, TRAIL. The structure reveals that a unique frame insertion of 12-16 amino, acids adopts a salient loop structure penetrating into the, receptor-binding site. The loop drastically alters the common, receptor-binding surface of the TNF family most likely for the specific, recognition of cognate partners. A structure-based mutagenesis study, demonstrates a critical role of the insertion loop in the cytotoxic, activity of TRAIL.
Disease
Known disease associated with this structure: Squamous cell carcinoma, head and neck OMIM:[603612]
About this Structure
1D2Q is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
2.8 A resolution crystal structure of human TRAIL, a cytokine with selective antitumor activity., Cha SS, Kim MS, Choi YH, Sung BJ, Shin NK, Shin HC, Sung YC, Oh BH, Immunity. 1999 Aug;11(2):253-61. PMID:10485660
Page seeded by OCA on Mon Nov 12 16:27:55 2007
