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1fzb

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[[Image:1fzb.jpg|left|200px]]
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{{Structure
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1fzb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fzb OCA], [http://www.ebi.ac.uk/pdbsum/1fzb PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1fzb RCSB]</span>
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'''CRYSTAL STRUCTURE OF CROSSLINKED FRAGMENT D'''
'''CRYSTAL STRUCTURE OF CROSSLINKED FRAGMENT D'''
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[[Category: Everse, S J.]]
[[Category: Everse, S J.]]
[[Category: Spraggon, G.]]
[[Category: Spraggon, G.]]
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[[Category: blood coagulation]]
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[[Category: Blood coagulation]]
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[[Category: fibrin]]
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[[Category: Fibrin]]
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[[Category: fibrinogen]]
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[[Category: Fibrinogen]]
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[[Category: plasma]]
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[[Category: Plasma]]
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[[Category: platelet]]
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[[Category: Platelet]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 16:56:05 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 20:33:13 2008''
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Revision as of 13:56, 2 May 2008

Image:1fzb.jpg

Template:STRUCTURE 1fzb

CRYSTAL STRUCTURE OF CROSSLINKED FRAGMENT D


Overview

In blood coagulation, units of the protein fibrinogen pack together to form a fibrin clot, but a crystal structure for fibrinogen is needed to understand how this is achieved. The structure of a core fragment (fragment D) from human fibrinogen has now been determined to 2.9 A resolution. The 86K three-chained structure consists of a coiled-coil region and two homologous globular entitles oriented at approximately 130 degrees to each other. Additionally, the covalently bound dimer of fragment D, known as 'double-D', was isolated from human fibrin, crystallized in the presence of a Gly-Pro-Arg-Pro-amide peptide ligand, which simulates the donor polymerization site, and its structure solved by molecular replacement with the model of fragment D.

About this Structure

1FZB is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structures of fragment D from human fibrinogen and its crosslinked counterpart from fibrin., Spraggon G, Everse SJ, Doolittle RF, Nature. 1997 Oct 2;389(6650):455-62. PMID:9333233 Page seeded by OCA on Fri May 2 16:56:05 2008

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