3a03

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==Crystal structure of Hox11L1 homeodomain==
==Crystal structure of Hox11L1 homeodomain==
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<StructureSection load='3a03' size='340' side='right' caption='[[3a03]], [[Resolution|resolution]] 1.54&Aring;' scene=''>
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<StructureSection load='3a03' size='340' side='right'caption='[[3a03]], [[Resolution|resolution]] 1.54&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3a03]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3A03 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3A03 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3a03]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3A03 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3A03 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3a01|3a01]], [[3a02|3a02]]</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3a01|3a01]], [[3a02|3a02]]</div></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">TLX2, HOX11L1, NCX ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">TLX2, HOX11L1, NCX ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3a03 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3a03 OCA], [http://pdbe.org/3a03 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3a03 RCSB], [http://www.ebi.ac.uk/pdbsum/3a03 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3a03 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3a03 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3a03 OCA], [https://pdbe.org/3a03 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3a03 RCSB], [https://www.ebi.ac.uk/pdbsum/3a03 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3a03 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/TLX2_HUMAN TLX2_HUMAN]] Transcription activator that binds DNA elements with the consensus sequence 5'-CGGTAATTGG-3'. Binds DNA via its homeobox. Required for normal cell death of enteric neurons in the gastrointestinal tract. Required for normal development of the enteric nervous system, and for proper development of normal motility of the gastrointestinal tract (By similarity).
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[[https://www.uniprot.org/uniprot/TLX2_HUMAN TLX2_HUMAN]] Transcription activator that binds DNA elements with the consensus sequence 5'-CGGTAATTGG-3'. Binds DNA via its homeobox. Required for normal cell death of enteric neurons in the gastrointestinal tract. Required for normal development of the enteric nervous system, and for proper development of normal motility of the gastrointestinal tract (By similarity).
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Human]]
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[[Category: Large Structures]]
[[Category: Kojima, T]]
[[Category: Kojima, T]]
[[Category: Miyazono, K]]
[[Category: Miyazono, K]]

Revision as of 16:13, 22 December 2021

Crystal structure of Hox11L1 homeodomain

PDB ID 3a03

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